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Keywords: Zebrafish
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Journal Articles
Biol Open (2023) 12 (6): bio059995.
Published: 27 June 2023
...Vanessa Chong-Morrison; Sarah Mayes; Filipa C. Simões; Upeka Senanayake; Dervla S. Carroll; Paul R. Riley; Stephen W. Wilson; Tatjana Sauka-Spengler ABSTRACT Due to its genetic amenability coupled with advances in genome editing, zebrafish is an excellent model to examine the function of (epi...
Includes: Supplementary data
Journal Articles
Biol Open (2023) 12 (6): bio059784.
Published: 15 June 2023
..., and the resultant protein interacts with FGFR1 in the FGF signaling pathway during development. Studies on flrt2 have focused mainly on its roles in the brain, heart and chondrogenesis. However, reports on its expression and function in the zebrafish retina are lacking. Here, we detected the high expression...
Journal Articles
Journal Articles
Biol Open (2023) 12 (4): bio059622.
Published: 7 April 2023
... in the process, but the underlying biology is still poorly understood. This is at least partially being explained by complexity and costs in using mammalian aging models. To understand aging-related vascular biology of impaired wound healing, we used zebrafish and turquoise killifish fin regeneration models...
Journal Articles
Biol Open (2023) 12 (1): bio059567.
Published: 31 January 2023
... models. Therefore, we took the approach of determining the effects of VPA treatment on zebrafish OT development as a first step in identifying the mechanisms that allow its formation. We describe normal OT development during the first 5 days of development and show that in VPA-treated embryos, neuronal...
Includes: Supplementary data
Journal Articles
Biol Open (2023) 12 (2): bio059810.
Published: 30 January 2023
... a common mechanism operates in these RREs. We identified three RREs from the zebrafish fn1b promoter by searching for conserved sequences within the surrounding genomic regions of regeneration-induced genes and performed a transgenic assay for regeneration response. Two regions contained in the transposons...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Biol Open (2022) 11 (10): bio059432.
Published: 18 October 2022
... in isolated zebrafish in which lateral line hair cells have been chemically ablated. These results suggest that modulation of pth2 by social context is acutely dependent on mechanosensory information from the lateral line. However, it is unclear how a congenital loss of lateral line function influences...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2022) 11 (8): bio059476.
Published: 16 August 2022
...Simon M. Hughes; Roberta C. Escaleira; Kees Wanders; Jana Koth; David G. Wilkinson; Qiling Xu ABSTRACT To address questions of stem cell diversity during skeletal myogenesis, a Brainbow-like genetic cell lineage tracing method, dubbed Musclebow2 , was derived by enhancer trapping in zebrafish...
Includes: Supplementary data
Journal Articles
Biol Open (2022) 11 (6): bio059150.
Published: 23 June 2022
... protein pacsin2 in endocytosis in the renal proximal tubule of zebrafish larvae. Pacsin2 is expressed throughout development and in all zebrafish tissues, similar to the mammalian orthologue. Within renal tubular epithelial cells, pacsin2 is enriched at the apical pole where it is localised to endocytic...
Includes: Supplementary data
Journal Articles
Biol Open (2022) 11 (3): bio058559.
Published: 9 March 2022
... into the mechanisms involved in the induction, maintenance, and resolution of inflammation. To that end, we developed a non-invasive, inducible, and reversible model of systemic inflammation in zebrafish. Using the Gal4-EcR/UAS system activated by the ecdysone analog tebufenozide, we generated transgenic zebrafish...
Journal Articles
Journal Articles
Biol Open (2021) 10 (9): bio058814.
Published: 20 September 2021
...Braedan M. McCluskey; Yipeng Liang; Victor M. Lewis; Larissa B. Patterson; David M. Parichy ABSTRACT Molecular and cellular mechanisms underlying variation in adult form remain largely unknown. Adult pigment patterns of fishes in the genus Danio , which includes zebrafish, Danio rerio , consist...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (9): bio058734.
Published: 9 September 2021
... tissue and systemic factors influence the differentiation of new adipocytes. While this could be studied in zebrafish, adipocyte identification currently relies on neutral lipid labeling, thus precluding access to cells in early stages of differentiation. Here we report the generation and analysis...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (9): bio058513.
Published: 2 September 2021
...Alexandra Lubin; Jason Otterstrom; Yvette Hoade; Ivana Bjedov; Eleanor Stead; Matthew Whelan; Gaia Gestri; Yael Paran; Elspeth Payne ABSTRACT Zebrafish provide a unique opportunity for drug screening in living animals, with the fast-developing, transparent embryos allowing for relatively high...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2021) 10 (3): bio058542.
Published: 9 March 2021
... for zebrafish cardiovascular mutants, we identified a mutation in the prkd2 gene. Homozygous mutant embryos develop as wild type up to 36 h post-fertilization and initiate blood flow, but fail to maintain it, resulting in a complete outflow tract stenosis. We identified a mutation in the prkd2 gene that results...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (3): bio056382.
Published: 8 March 2021
...Rui Guo; Fei Li; Minxia Lu; Kangkang Ge; Lin Gan; Donglai Sheng ABSTRACT LIM homeobox 9 (Lhx9) is a member of the LIM homeodomain transcription factor family, which expresses and functions in various vertebrate tissues, such as the gonads and pineal gland. Previous studies on lhx9 in zebrafish have...
Includes: Supplementary data