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Keywords: Xenopus
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Journal Articles
Biol Open (2021) 10 (7): bio056887.
Published: 12 July 2021
..., the endolysosomal system emerges as an important regulator at different levels, but in vivo studies are rare. In the frog Xenopus , little is known about the developmental roles of endosomal regulators, or their potential involvement in signaling, especially for late endosomes. Here, we analyzed a hypothesized role...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (3): bio038422.
Published: 4 March 2019
... the anterior-posterior body axis and the timing of expression during development, and these correlations are called spatial and temporal collinearity, respectively. Here we studied the expression dynamics of all hox genes of the diploid species Xenopus tropicalis in four Hox clusters (A–D) by analyzing high...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (10): 1528–1540.
Published: 4 September 2017
... the regulation and function of vestigial-like 3 (vgll3) during Xenopus early development. A combination of signals, including FGF8, Wnt8a, Hoxa2, Hoxb2 and retinoic acid, limits vgll3 expression to hindbrain rhombomere 2. We show that vgll3 regulates trigeminal placode and nerve formation and is required...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (10): 1445–1457.
Published: 17 August 2017
... early in Xenopus embryos. Blocking HCN channels ( I h currents) with pharmacological inhibitors leads to errors in organ situs. This effect is only seen when HCN4 channels are blocked early (pre-stage 10) and not by a later block (post-stage 10). Injections of HCN4-DN (dominant-negative) mRNA induce...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (6): 801–806.
Published: 23 May 2016
... show that amyloids form as a normal part of Xenopus oocyte development. Amyloids are detectable in the cytosol and the nucleus using an amyloid binding dye and antibodies that recognize amyloid structure. In the cytosol, yolk platelets are amyloid reactive, as are a number of yet to be characterized...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (6): 722–730.
Published: 14 July 2015
..., their subcellular localization and the mode of action have remained largely unknown. Here we describe the anteroposterior planar cell polarity (AP-PCP) of the cells in the Xenopus neural plate. At the neural midline, the Vangl2 protein is enriched at anterior cell edges and that this localization is directed...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (4): 573–583.
Published: 6 March 2015
... BMP antagonist, can convert pluripotent Xenopus laevis animal cap cells to functional retinal cells. The aim of this study is to determine the intracellular molecular events that occur during this conversion. Surprisingly, blocking BMP signaling alone failed to mimic Noggin treatment. Overexpressing...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (12): 1279–1287.
Published: 6 November 2013
... species, including mice, zebrafish, Xenopus and Drosophila . In this study we focus on the physical properties of Xenopus laevis PGCs during their transition from the passive to the active migratory state. Pre-migratory PGCs from Xenopus laevis embryos at developmental stages 17–19 to be compared...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (9): 882–890.
Published: 11 July 2013
... for certain aspects, e.g. no direct accessibility of embryonic stages, or non-straightforward visualization of early lymphatic sprouting, respectively. We previously demonstrated that the Xenopus tadpole is a valuable model to study the processes of lymphatic development. However, a fluorescent Xenopus...
Includes: Multimedia, Supplementary data
Journal Articles
Biol Open (2013) 2 (3): 306–313.
Published: 17 January 2013
... in transmembrane resting potential initiate Xenopus tadpole tail regeneration, including regrowth of a functioning spinal cord, in tails that have been inhibited by natural inactivity of the endogenous H + -V-ATPase pump. However, existing pharmacological and genetic methods allow neither non-invasive control...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (12): 1264–1272.
Published: 16 October 2012
... in eucaryotic organisms. Mol. Cell. Biol. 20 , 429 – 440 . 10.1128/MCB.20.2.429-440.2000 McDowell G. S. , Kucerova R. , Philpott A. ( 2010 ). Non-canonical ubiquitylation of the proneural protein Ngn2 occurs in both Xenopus embryos and mammalian cells. Biochem. Biophys. Res...