...Johanna Örling; Katri Kosonen; Jenna Villman; Martin Reichard; Ilkka Paatero ABSTRACT Impaired wound healing is associated with aging and has significant effects on human health on an individual level, but also on the whole health-care sector. Deficient angiogenesis appears to be involved...

... for Yorkie-induced endoreplication and cell fusion. As a result, wound healing is perturbed when focal adhesion genes are knocked down. These findings show that conserved focal adhesion signaling is required to initiate wound-induced polyploid cell growth. * Author for correspondence ( vicki.losick...

... connected and the dysregulation of mitochondrial dynamics is linked to several human diseases. In this work, we investigated the role of mitochondrial dynamics in wound healing in the Drosophila embryonic epidermis. Mutants for mitochondrial fusion and fission proteins fail to close their wounds, indicating...

...Joshua D. Currie; Lidia Grosser; Prayag Murawala; Maritta Schuez; Martin Michel; Elly M. Tanaka; Tatiana Sandoval-Guzmán ABSTRACT The heterogeneous properties of dermal cell populations have been posited to contribute toward fibrotic, imperfect wound healing in mammals. Here we characterize...

...Yan Liu; Sandeep Dhall; Anthony Castro; Alex Chan; Raquelle Alamat; Manuela Martins-Green ABSTRACT Wound healing is a complex process that involves sequential phases that overlap in time and space and affect each other dynamically at the gene and protein levels. We previously showed that insulin...

...Jie Zhou; Xipeng Zhang; Pengfei Liang; Licheng Ren; Jizhang Zeng; Minghua Zhang; Pihong Zhang; Xiaoyuan Huang ABSTRACT Our previous study has suggested that downregulated microRNA (miR)-29a in denatured dermis might be involved in burn wound healing. However, the exact role of miR-29a in healing...

... undetectable until several days later. This “cell type traffic” regulation ensures proper healing of the wound, as disruptions of the regulation could either cause delay of wound healing or result in hypertrophic scars. TGFβ3 is the critical traffic controller that selectively halts migration of the dermal...

...) a denervated limb that will not regenerate a limb, and 3) an innervated limb that will regenerate a limb. Early, histological and transcriptional changes were similar between the injury types, presumably because a common wound-healing program is employed across anatomical locations. However, some transcripts...