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Keywords: Wnt7a
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Journal Articles

Overexpression of Wnt7a enhances radiosensitivity of non-small-cell lung cancer via the Wnt/JNK pathway

Pingping Ai, Xianhua Xu, Shijie Xu, Zhixia Wei, Shun Tan, Junzhe Li
Journal: Biology Open
Biol Open (2020) 9 (6): bio050575.
https://doi.org/10.1242/bio.050575
Published: 27 June 2020
...Pingping Ai; Xianhua Xu; Shijie Xu; Zhixia Wei; Shun Tan; Junzhe Li ABSTRACT The Wingless-type protein 7a (Wnt7a) plays an antiproliferative role in non-small-cell lung cancer (NSCLC). Previous studies have indicated that Wnt7a expression was downregulated in radiation-resistant NSCLC cells...
View articletitled, Overexpression of Wnt7a enhances radiosensitivity of non-small-cell lung cancer via the Wnt/JNK pathway
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Journal Articles

hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression

Sreedevi Avasarala, Michelle Van Scoyk, Jianbin Wang, Marybeth Sechler, Katherine Vandervest, Christine Brzezinski, Colin Weekes, Michael G. Edwards, John Arcaroli, Richard E. Davis, Rama Kamesh Bikkavilli, Robert A. Winn
Journal: Biology Open
Biol Open (2013) 2 (7): 675–685.
https://doi.org/10.1242/bio.20134507
Published: 22 May 2013
... independent signaling, via Wnt7a/Frizzled9 signaling, leads to reversal of cellular transformation, reduced anchorage-independent growth and induction of epithelial differentiation. miRNA expression profiling on a human lung adenocarcinoma cell line (A549) identified hsa-miR29b as an important downstream...
View articletitled, hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression
Open the PDF for hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression in another window
Includes: Supplementary data
Journal Articles

The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs

Mako Yamamoto, Tomoko Matsuzaki, Rei Takahashi, Eijiro Adachi, Yasuhiro Maeda, Sachiyo Yamaguchi, Hitoshi Kitayama, Michiko Echizenya, Yoko Morioka, David B. Alexander, Takeshi Yagi, Shigeyoshi Itohara, Takashi Nakamura, Haruhiko Akiyama, Makoto Noda
Journal: Biology Open
Biol Open (2012) 1 (5): 458–466.
https://doi.org/10.1242/bio.2012638
Published: 27 March 2012
... Wnt7a and Igf2 expression, and hypotrophy in two signaling centers (i.e., ZPA and AER) that are essential for limb outgrowth and patterning. Reck is abundantly expressed in the anterior mesenchyme in normal limb buds; mesenchyme-specific Reck inactivation recapitulates the low- Reck phenotype; and some...
View articletitled, The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs
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Includes: Supplementary data