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Keywords: WNK
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Journal Articles
Katsuyuki Oi, Eisei Sohara, Tatemitsu Rai, Moko Misawa, Motoko Chiga, Dario R. Alessi, Sei Sasaki, Shinichi Uchida
Journal:
Biology Open
Biol Open (2012) 1 (2): 120–127.
Published: 24 November 2011
... that WNK kinases phosphorylate and activate OSR1/SPAK kinases that regulate renal SLC12A family transporters such as NKCC2 and NCC, and clarified that the constitutive activation of this cascade causes PHAII. WNK3, another member of the WNK kinase family, was reported to be a strong activator of NCC/NKCC2...
Includes: Supplementary data
