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Keywords: Vascularization
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Journal Articles

Formation of the sacrum requires down-regulation of sonic hedgehog signaling in the sacral intervertebral discs

Raffaella Bonavita, Kathleen Vincent, Robert Pinelli, Chitra Lekha Dahia
Journal: Biology Open
Biol Open (2018) 7 (7): bio035592.
https://doi.org/10.1242/bio.035592
Published: 24 July 2018
... Sacrum disc Vascularization We have previously shown that SHH is important for the maintenance of the lumbar discs, and its loss is associated with the aging phenotype of the NP cells in these discs ( Dahia et al., 2012 ; Winkler et al., 2014 ). Here, we show that there is a physiological loss...
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Includes: Supplementary data