... understand how signal transduction pathways regulate diverse vascular responses. The vascular endothelial growth factor (VEGF) family bind membrane-bound receptor tyrosine kinases (VEGFRs), which trigger multiple signal transduction pathways and diverse cellular responses. We evaluated whether the MAP3K...

... defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 2 (VEGFR2) regulate signal transduction and angiogenesis, but how signaling and proteolysis is regulated is not well understood. Here, we provide evidence that a pathway requiring the E1 ubiquitin...

...Gareth W. Fearnley; Gina A. Smith; Izma Abdul-Zani; Nadira Yuldasheva; Nadeem A. Mughal; Shervanthi Homer-Vanniasinkam; Mark T. Kearney; Ian C. Zachary; Darren C. Tomlinson; Michael A. Harrison; Stephen B. Wheatcroft; Sreenivasan Ponnambalam ABSTRACT Vascular endothelial growth factor A (VEGF...

...Ayumi Yoshida; Akio Shimizu; Hirotsugu Asano; Tetsuya Kadonosono; Shinae Kizaka Kondoh; Elena Geretti; Akiko Mammoto; Michael Klagsbrun; Misuzu Kurokawa Seo ABSTRACT Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF...

...Gareth W. Fearnley; Alexander F. Bruns; Stephen B. Wheatcroft; Sreenivasan Ponnambalam Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist...