...Sweta Jha; Johanna Pispa; Carina I. Holmberg ABSTRACT The autophagy–lysosomal pathway (ALP) and the ubiquitin–proteasome system (UPS) are the two major intracellular proteolytic systems that mediate protein turnover in eukaryotes. Although a crosstalk exists between these two systems, it is still...

...Chika Higuchi; Mari Yamamoto; Seung-Wook Shin; Kei Miyamoto; Kazuya Matsumoto ABSTRACT During the maternal-to-zygotic transition (MZT), mRNAs and proteins stored in oocytes are degraded and zygotic genes are activated. We have previously shown that the ubiquitin-proteasome system (UPS)-mediated...

... are degraded by the ubiquitin–proteasome system (UPS), and new proteins are synthesized from the zygotic genome. However, the specific mechanisms underlying the UPS at the MZT are not well understood. We identified a molecule named zygote-specific proteasome assembly chaperone (ZPAC) that is specifically...