...Jessica R. Blount; Danielle N. Meyer; Camille Akemann; Sean L. Johnson; Katherine Gurdziel; Tracie R. Baker; Sokol V. Todi ABSTRACT The small protein modifier ubiquitin regulates various aspects of cellular biology through its chemical conjugation onto proteins. Ubiquitination of proteins presents...

...Jiude Mao; Chad O'Gorman; Miriam Sutovsky; Michal Zigo; Kevin D. Wells; Peter Sutovsky ABSTRACT Ubiquitin A-52 residue ribosomal protein fusion product 1 ( Uba52 ), a ubiquitin-ribosomal fusion gene, is a major source of ubiquitin protein for covalent modification of proteinaceous substrates...

...; Shane O'Conchúir; Danielle L. Swaney; Eric D. Chow; Hiten D. Madhani; Sy Redding; Daniel N. Bolon; Tanja Kortemme; Joseph L. DeRisi; Martin Kampmann; James S. Fraser ABSTRACT Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant...

...-translationally. This protein is especially accumulated in and critical for the survival of DNA-damaged cells. Cell cycle DNA damage response Ubiquitin Protein degradation CCCH-zinc finger domain RNA-binding protein The expression of many cell cycle regulatory proteins is strictly controlled...

... mechanism is based on feedback loops involving clock genes and their protein products. Post-translational modifications, including ubiquitination, are important for regulating the clock feedback mechanism. Previous work has focused on the role of ubiquitin ligases in the clock mechanism. Here we show a role...

...Saili Moghe; Fei Jiang; Yoshie Miura; Ronald L. Cerny; Ming‐Ying Tsai; Manabu Furukawa Summary The cullin‐RING family of ubiquitin ligases regulates diverse cellular functions, such as cell cycle control, via ubiquitylation of specific substrates. CUL3 targets its substrates through BTB proteins...