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Keywords: Trastuzumab
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Journal Articles
Carolina D'Alesio, Grazia Bellese, Maria Cristina Gagliani, Anastasia Lechiara, Martina Dameri, Elena Grasselli, Luisa Lanfrancone, Katia Cortese, Patrizio Castagnola
Journal:
Biology Open
Biol Open (2019) 8 (4): bio038323.
Published: 18 April 2019
... represents a mechanism of resistance against Trastuzumab (Tz), a therapeutic anti-ERBB2 antibody. We show that CHD4 depletion in two ERBB2 + BC cell lines strongly inhibits cell proliferation, induces p27 KIP1 upregulation, Tyr 1248 ERBB2 phosphorylation, ERK1/2 and AKT dephosphorylation, and downregulation...
Includes: Supplementary data
