... have revealed regulatory paradigms for stem cell self-renewal and differentiation. The germarium of the female Drosophila gonad, which houses both germline and somatic stem cells, is one such model system. Bulk mRNA sequencing (RNA-seq), single-cell RNA-seq (scRNA-seq), and bulk translation efficiency...

... of translationally competent eIF2/GTP/tRNA i Met ternary complex, and inhibits translation initiation. In contrast to SA, 15d-PGJ2-dependent SG formation is independent of eIF2α phosphorylation. Rather it targets eIF4A and inhibits the interaction between eIF4A-eIF4G, leading to inhibition of translation...

... with an increased aggregation propensity. The aggregated proteins have high translation rates and are substrates of ribosome-associated Hsp70 chaperones, indicating that they are susceptible for aggregation primarily during translation/folding. The aggregation-prone proteins are enriched for multiple chaperone...