..., control cells were treated with doxycycline at a level such that the BirA expression matched that of the experimental cell line. GATA Endoderm development Pluripotent stem cell differentiation Transcriptional control Summary: Using the differentiation of huESCs as a model for endoderm...

... modification of the orb locus. Our data indicate that H3K36me3-mediated epigenetic regulation is activated by bam , and that this modification facilitates germ cell differentiation, probably through transcriptional activation. This work provides a novel link between Bam and epigenetic transcriptional control...