... are less well studied. Neurons are a post-mitotic cell-type with highly specialised functions that largely lack the capacity for renewal. Therefore, neuronal cell identities and the transcriptional states that underpin them are locked into place by active mechanisms that prevent lineage reversion...

...-site in exploring post-transcriptional gene expression changes. Fig. 4. Ord expression is controlled post-transcriptionally. (A,B) Visualization of expression of ord over germline development from (A) bulk RNA-seq of developmentally enriched stages and (B) polysome-seq of developmentally...

... to 3D tissue culture is required. Single molecule RNA fluorescence in situ hybridization (smFISH) is a robust technique for visualizing and quantifying individual transcripts. In addition, smFISH can be employed to study splice variants, fusion transcripts as well as transcripts of multiple genes...

...Alexandre Neves; Robert N. Eisenman ABSTRACT The transcriptional mechanisms that allow neural stem cells (NSC) to balance self-renewal with differentiation are not well understood. Employing an in vivo RNAi screen we identify here NSC-TAFs, a subset of nine TATA-binding protein associated factors...

...Ying Liu; Rita Cerejeira Matos; Tapio I. Heino; Ville Hietakangas ABSTRACT PWP1 is a chromatin binding protein with an important role in animal growth control downstream of mTOR-mediated nutrient sensing. PWP1 has been shown to control tissue growth by promoting the transcription of 5.8S, 18S...

.... and Li , L. ( 2006 ). The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells . Leukemia   20 , 417 - 425 . 10.1038/sj.leu.2404105 Yang , J. , Yan , R. , Roy , A. , Xu , D. , Poisson , J. and Zhang , Y...

...) and NIPBL interact with Mediator complexes along with RNA polymerase II that bring long-distance enhancers to close proximity of the promoter of transcriptionally active genes via a cis -mediated DNA looping event ( Kagey et al., 2010 ). The molecular mechanism underlying RBS is thought to occur through...

... fertility while males appear to mate and reproduce normally ( Chomez et al., 2000 ). Circadian clock Transcription Physiology Summary: The hepatokine Fgf21 is transcriptionally regulated by the nuclear receptor REV-ERBα with the hepatocyte-specific factor HNF6 to regulate metabolism...

... function of Top2b in proper development and the maintenance/survival of postmitotic neurons in the retina. Cell survival Gene regulation Postmitotic cells Retina Top2b Transcription Retina degeneration * Authors for correspondence ( lcai@rutgers.edu ; lyuyi@rwjms.rutgers.edu...

...Shu Shien Chin; Rose-Anne Romano; Priyadharsini Nagarajan; Satrajit Sinha; Lee Ann Garrett-Sinha Summary The transcription factor Ets1 is expressed at low levels in epidermal keratinocytes under physiological conditions, but is over-expressed in cutaneous squamous cell carcinoma (SCC). We...

...://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. ES cells Enhancer Haematopoiesis Transcription The intricate process of embryonic development involves dynamic interactions...