...Chun Chih Chen; William S. Marshall; George N. Robertson; Regina R. F. Cozzi; Scott P. Kelly ABSTRACT Claudin (Cldn)-10 tight junction (TJ) proteins are hypothesized to form the paracellular Na + secretion pathway of hyposmoregulating mummichog ( Fundulus heteroclitus ) branchial epithelia. Organ...

...Rie Sonoi; Yoshihisa Hagihara ABSTRACT Entacapone (ENT), a catechol- O -methyltransferase inhibitor, causes liver injury by inducing bile canaliculi (BC) dilation through inhibition of the myosin light kinase pathway. Loss of tight junctions (TJs) induces hepatocyte depolarization, which causes...

... regulate molecular transport. Despite the critical functions of the CNS barriers, the mechanisms underlying their development and function are not well understood, and there are very limited experimental models for their study. Claudin 5 is a tight junction protein required for blood brain barrier (BBB...

...-known mechanism, the dialogue between those signals and factors remains to be unveiled. Here, we identify a requirement for MarvelD3, a tight junction transmembrane protein, in eye morphogenesis in Xenopus . MarvelD3 depletion led to an abnormally pigmented eye or even an eye-less phenotype, which...

...Shin-ichiro Kitajiri; Tatsuya Katsuno; Hiroyuki Sasaki; Juichi Ito; Mikio Furuse; Shoichiro Tsukita ABSTRACT Occludin is the first identified protein in the tight junction (TJ), but its function has remained for the most part obscure. TJs have been demonstrated to play important roles in the inner...

... localization both in epithelial and mesenchyme-like cells. Receptor for Activated protein Kinase C (RACK1), which we identified as an xMELK partner, co-localizes with xMELK at the tight junction. Moreover, a truncated RACK1 construct interferes with iMELK localization at cell–cell contacts. Collectively, our...

...María Teresa Ortiz-Melo; Erika Sánchez-Guzmán; Arturo González-Robles; Jesús Valdés; Eber Gómez-Flores; Federico Castro-Muñozledo Summary Although tight junctions (TJ) have been extensively studied in simple epithelial cells, it is still unknown whether their organization is coupled to cell...