...D. S. Davies; A. T. Arthur; H. L. Aitken; B. Crossett; C. S. Goldsbury ABSTRACT Mouse monoclonal 12E8 antibody, which recognises conserved serine phosphorylated KXGS motifs in the microtubule binding domains of tau/tau-like microtubule associated proteins (MAPs), shows elevated binding in brain...

... Apoptosis Entorhinal cortex Excitotoxicity Glia activation Inflammation Oxidative stress Tau Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in widespread neuropathology throughout the brain, and severe disruption of cognitive and mnemonic function ( Calderon...

...Edward F. Boumil; Rishel B. Vohnoutka; Sangmook Lee; Thomas B. Shea ABSTRACT Tau impacts overall axonal transport particularly when overexpressed by interfering with translocation of kinesin along microtubules (MTs) and/or as a cargo of kinesin by outcompeting other kinesin cargo. To discern...

... and fission) and cellular energy generation. Thus, Miro might be associated with the key pathologies of several neurodegenerative diseases (NDs) including Alzheimer's disease (AD). In the present manuscript, we have demonstrated the possible genetic interaction between Miro and AD-related genes such as Tau...

...Alessia Galasso; Charles S. Cameron; Bruno G. Frenguelli; Kevin G. Moffat ABSTRACT Neurodegenerative tauopathies are characterised by accumulation of hyperphosphorylated tau aggregates primarily degraded by autophagy. The 5′AMP-activated protein kinase (AMPK) is expressed in most cells, including...

...Giulia Povellato; Richard I. Tuxworth; Diane P. Hanger; Guy Tear Summary Hyperphosphorylation of the microtubule associated protein, Tau, is the hallmark of a group of neurodegenerative disorders known as the tauopathies which includes Alzheimer's disease. Precisely how and why Tau phosphorylation...