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Keywords: Stemness
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Journal Articles

SRRM2 splicing factor modulates cell fate in early development

Silvia Carvalho, Luna Zea-Redondo, Tsz Ching Chloe Tang, Philipp Stachel-Braum, Duncan Miller, Paulo Caldas, Alexander Kukalev, Sebastian Diecke, Stefanie Grosswendt, Ana Rita Grosso, Ana Pombo
Journal: Biology Open
Biol Open (2024) 13 (4): bio060415.
https://doi.org/10.1242/bio.060415
Published: 24 April 2024
... to guide cell differentiation and fate decisions. The Srrm2 splicing factor has recently been implicated in developmental disorders and diseases, but its role in early mammalian development remains unexplored. Here, we show that Srrm2 dosage is critical for maintaining embryonic stem cell pluripotency...
View article titled, SRRM2 splicing factor modulates cell fate in early development
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Includes: Supplementary data
Journal Articles

A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling

Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic
Journal: Biology Open
Biol Open (2021) 10 (2): bio050211.
https://doi.org/10.1242/bio.050211
Published: 9 February 2021
...Katherine K. Slemmons; Michael D. Deel; Yi-Tzu Lin; Kristianne M. Oristian; Nina Kuprasertkul; Katia C. Genadry; Po-Han Chen; Jen-Tsan Ashley Chi; Corinne M. Linardic ABSTRACT The development of three-dimensional cell culture techniques has allowed cancer researchers to study the stemness...
View article titled, A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in <span class="search-highlight">stemness</span> and Notch signaling
Open the PDF for A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in <span class="search-highlight">stemness</span> and Notch signaling in another window
Includes: Supplementary data
Journal Articles

Soft substrate maintains proliferative and adipogenic differentiation potential of human mesenchymal stem cells on long-term expansion by delaying senescence

Sanjay Kumar Kureel, Pankaj Mogha, Akshada Khadpekar, Vardhman Kumar, Rohit Joshi, Siddhartha Das, Jayesh Bellare, Abhijit Majumder
Journal: Biology Open
Biol Open (2019) 8 (4): bio039453.
https://doi.org/10.1242/bio.039453
Published: 26 April 2019
...Sanjay Kumar Kureel; Pankaj Mogha; Akshada Khadpekar; Vardhman Kumar; Rohit Joshi; Siddhartha Das; Jayesh Bellare; Abhijit Majumder ABSTRACT Human mesenchymal stem cells (hMSCs), during in vitro expansion, gradually lose their distinct spindle morphology, self-renewal ability, multi-lineage...
View article titled, Soft substrate maintains proliferative and adipogenic differentiation potential of human mesenchymal <span class="search-highlight">stem</span> cells on long-term expansion by delaying senescence
Open the PDF for Soft substrate maintains proliferative and adipogenic differentiation potential of human mesenchymal <span class="search-highlight">stem</span> cells on long-term expansion by delaying senescence in another window
Includes: Supplementary data