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Keywords: Stem cells
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Biol Open (2024) 13 (1): bio059919.
Published: 22 January 2024
... of stem cells in the basal layer: Keratin 15 + ( Krt15 + ) cells. However, little is known about the molecular mechanisms regulating their distinct features, namely self-renewal, potency and epithelial regeneration. Achaete-scute family BHLH transcription factor 2 (ASCL2) is strongly upregulated in Krt15...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (11): bio058623.
Published: 3 November 2021
... as a model, we have recently described that adult intestinal stem cells (ISCs), do not activate programmed cell death upon aneuploidy induction, leading to an increase in ISC proliferation rate, and tissue dysplasia. How aneuploidy impacts ISCs in intestinal tumorigenic models remains to be investigated...
Includes: Supplementary data
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Journal Articles
Biol Open (2021) 10 (4): bio058526.
Published: 23 April 2021
...William R. Jeffery; Špela Gorički ABSTRACT In the ascidian Ciona intestinalis , basal body parts regenerate distal structures but distal body parts do not replace basal structures. Regeneration involves the activity of adult stem cells in the branchial sac, which proliferate and produce migratory...
Journal Articles
Biol Open (2020) 9 (9): bio052381.
Published: 21 September 2020
... pathways involved in cardiac hypertrophy, there is a need for improved in vitro models. In this study, we investigated how hypertrophic stimulation affected human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs). The cells were stimulated with endothelin-1 (ET-1) for 8, 24, 48, 72, or 96 h...
Includes: Supplementary data
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Journal Articles
Biol Open (2019) 8 (8): bio042812.
Published: 9 August 2019
.../j.ydbio.2016.10.016 Basak , O. , Beumer , J. , Wiebrands , K. , Seno , H. , van Oudenaarden , A. and Clevers , H. ( 2017 ). Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells . Cell Stem Cell...
Includes: Supplementary data
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Biol Open (2019) 8 (5): bio037937.
Published: 1 May 2019
...-renewing undifferentiated state akin to trophoblast stem cells described in other species. Functional features uncovered are essential for understanding early events in bovine pregnancy towards initiation of implantation. * Author for correspondence ( [email protected] ) Competing interests...
Includes: Supplementary data
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Biol Open (2017) 6 (7): 979–992.
Published: 15 July 2017
... regeneration of the neural retina and retinal pigment epithelium in the embryonic chick. Cell fate Progenitors Retinal pigment epithelium Regeneration Retina Stem cells Transdifferentiation Re-specification In vertebrates, the retinal pigment epithelium (RPE) is a single-layered pigmented...
Includes: Supplementary data
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Journal Articles
Biol Open (2014) 3 (12): 1236–1244.
Published: 28 November 2014
...Niraimathi Govindasamy; Supriya Murthy; Yashoda Ghanekar ABSTRACT Adult stem cells face the challenge of maintaining tissue homeostasis by self-renewal while maintaining their proliferation potential over the lifetime of an organism. Continuous proliferation can cause genotoxic/metabolic stress...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2012) 1 (4): 341–352.
Published: 7 February 2012
... of the Creative Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). Stem cells NuRD DNA methylation Trophectoderm Chromatin The first lineage commitment event during early mammalian development results in the segregation of two distinct...
Includes: Supplementary data
Journal Articles