...Bareqa Salah; Diana Shahin; Momen Sarhan; Joud Al-Karmi; Ban Al-Kurdi; Renata Al-Atoom; Mohammad A. Ismail; Nouran Hammad; Hanan Jafar; Abdalla Awidi; Nidaa A. Ababneh ABSTRACT Cigarette smoking negatively impacts mesenchymal stem cell functionality, including proliferation, viability...

...Miriana Dardano; Tamina Lebek; Ingrid H. C. Tsang ABSTRACT Each year, the European Summer School on Stem Cell Biology and Regenerative Medicine (SCSS) attracts early-career researchers and actively practicing clinicians who specialise in stem cell and regenerative biology. The 16th edition...

...Chengcheng Li; Sen Ren; Hewei Xiong; Jing Chen; Tao Jiang; Jiahe Guo; Chengqi Yan; Zhenbing Chen; Xiaofan Yang; Xiang Xu ABSTRACT Adipose-derived stem cells (ADSCs) have been widely applied in translational and regenerative medicine. During aging, there is a recognized functional decline in ADSCs...

... of stem cells in the basal layer: Keratin 15 + ( Krt15 + ) cells. However, little is known about the molecular mechanisms regulating their distinct features, namely self-renewal, potency and epithelial regeneration. Achaete-scute family BHLH transcription factor 2 (ASCL2) is strongly upregulated in Krt15...

... as a model, we have recently described that adult intestinal stem cells (ISCs), do not activate programmed cell death upon aneuploidy induction, leading to an increase in ISC proliferation rate, and tissue dysplasia. How aneuploidy impacts ISCs in intestinal tumorigenic models remains to be investigated...

...Aaron M. Savage; Ramiro Alberio; Andrew D. Johnson ABSTRACT In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One...

...William R. Jeffery; Špela Gorički ABSTRACT In the ascidian Ciona intestinalis , basal body parts regenerate distal structures but distal body parts do not replace basal structures. Regeneration involves the activity of adult stem cells in the branchial sac, which proliferate and produce migratory...

... pathways involved in cardiac hypertrophy, there is a need for improved in vitro models. In this study, we investigated how hypertrophic stimulation affected human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs). The cells were stimulated with endothelin-1 (ET-1) for 8, 24, 48, 72, or 96 h...

...Manu D. Tiwari; Daniela M. Zeitler; Gunter Meister; Andreas Wodarz ABSTRACT Stem cells can self-renew and produce daughter cells destined for differentiation. The precise control of the balance between these two outcomes is essential to ensure tissue homeostasis and to prevent uncontrolled...

.../j.ydbio.2016.10.016 Basak , O. , Beumer , J. , Wiebrands , K. , Seno , H. , van Oudenaarden , A. and Clevers , H. ( 2017 ). Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells . Cell Stem Cell...

...-renewing undifferentiated state akin to trophoblast stem cells described in other species. Functional features uncovered are essential for understanding early events in bovine pregnancy towards initiation of implantation. Primary culture conditions for in vitro attachment and trophoblast growth were...

... regeneration of the neural retina and retinal pigment epithelium in the embryonic chick. Cell fate Progenitors Retinal pigment epithelium Regeneration Retina Stem cells Transdifferentiation Re-specification In vertebrates, the retinal pigment epithelium (RPE) is a single-layered pigmented...

...Takumi Miura; Tohru Sugawara; Atsushi Fukuda; Ryo Tamoto; Tomoyuki Kawasaki; Akihiro Umezawa; Hidenori Akutsu ABSTRACT In mice, leukemia inhibitory factor (LIF)-dependent primitive neural stem cells (NSCs) have a higher neurogenic potential than bFGF-dependent definitive NSCs. Therefore, expandable...

...Niraimathi Govindasamy; Supriya Murthy; Yashoda Ghanekar ABSTRACT Adult stem cells face the challenge of maintaining tissue homeostasis by self-renewal while maintaining their proliferation potential over the lifetime of an organism. Continuous proliferation can cause genotoxic/metabolic stress...

...Toma Yakulov; Ufuk Günesdogan; Herbert Jäckle; Alf Herzig ABSTRACT Stem cells continuously generate differentiating daughter cells and are essential for tissue homeostasis and development. Their capacity to self-renew as undifferentiated and actively dividing cells is controlled by either external...

... of the Creative Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). Stem cells NuRD DNA methylation Trophectoderm Chromatin The first lineage commitment event during early mammalian development results in the segregation of two distinct...

...Brian G. Ballios; Laura Clarke; Brenda L. K. Coles; Molly S. Shoichet; Derek Van Der Kooy Summary Self-renewing, multipotential retinal stem cells (RSCs) reside in the pigmented ciliary epithelium of the peripheral retina in adult mammals. RSCs can give rise to rhodopsin positive-cells, which can...