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Keywords: Src
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Journal Articles
Biol Open (2019) 8 (3): bio038406.
Published: 18 March 2019
... and maintained. This study focuses on the kinases Mbt/PAK4 and SRC, both known to alter E-Cadherin AJ across phyla. Drosophila p21-activated kinase Mbt and the non-receptor tyrosine kinases Src64 and Src42 regulate proper N-Cadherin AJ. N-Cadherin AJ elongation depends on SRC kinase activity. Cell culture...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (1): 32–44.
Published: 23 December 2015
... phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway which represses RhoA-myosin-dependent contractility. Using PTP1B null (KO) cells and PTP1B reconstituted (WT) cells, we determined that some early steps following cell adhesion to fibronectin and vitronectin occurred...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (8): 1024–1039.
Published: 8 July 2015
... have found significant correlations in human epithelial cancer datasets between the high expression of BTB-ZF oncogenes, Bcl6 and ZBTB7A , and low expression of Dlg2 or Llgl1 cell polarity genes or high expression of ArhGef11 , ArhGef12, MAP2K4, MAP2K7, MAPK8, MAPK9, MAPK10, Src or Yes1...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (2): 129–137.
Published: 3 January 2014
...-cadherin gene repression to trigger EMT and, in addition, promote FAK/Src pathway activation to support EMT. These findings reveal a non-conventional role of LOXL2 on regulating epithelial cell plasticity. HEK293T and MDCK-II cell lines were obtained from the American Type Culture Collection...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (4): 416–423.
Published: 26 February 2013
... scrape-healing assay, then a second round using a 3-dimensional tubulogenesis assay; both of these rounds use new cell lines described in this report. The final stage is ex vivo organ culture. We demonstrate the utility of the screen by using it to identify the FAK–Src-pathway signalling as being...
Includes: Supplementary data
Journal Articles