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Keywords: Spindle assembly checkpoint
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Journal Articles
Biol Open (2021) 10 (11): bio058623.
Published: 3 November 2021
... phenotypes in the Drosophila gut, we found that concomitant aneuploidy induction by impairment of the spindle assembly checkpoint (SAC) consistently leads to a more severe progression of intestinal dysplasia or tumorigenesis. This is characterized by an accumulation of progenitor cells, high tissue cell...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (6): bio037424.
Published: 12 June 2019
...Lydia R. Heasley; Jennifer G. DeLuca; Steven M. Markus ABSTRACT The spindle assembly checkpoint (SAC) prevents erroneous chromosome segregation by delaying mitotic progression when chromosomes are incorrectly attached to the mitotic spindle. This delay is mediated by mitotic checkpoint complexes...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (11): 1674–1679.
Published: 15 November 2016
...Marie Duranteau; Jean-Jacques Montagne; Zohra Rahmani ABSTRACT The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate segregation of chromosomes into two daughter cells. BubR1, a key component of the SAC, also plays a role in the mitotic timing since depletion...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (6): 522–528.
Published: 29 May 2014
... missegregation, whereas its depletion in mammalian cells leads to chromosome segregation defects despite the presence of a functional spindle assembly checkpoint (SAC). Cenp-meta has previously been reported to be the Drosophila homolog of vertebrate Cenp-E. In this study, we show that cenp-metaΔ mutant...
Includes: Multimedia, Supplementary data