... germline-specific degradation of Integrator results in the accumulation of misprocessed snRNA transcript, it did not impair the development or lifespan but surprisingly increased progeny production. Together, our study illustrates a temporal, and a potentially tissue-specific requirement of the Integrator...

... of the small nuclear RNA (snRNA) component of the snRNP. The protein WRAP53 binds a sequence motif (the CAB box) found in many scaRNAs and the RNA component of telomerase (hTR) and targets these RNAs to the CB. We have previously reported that coilin, the CB marker protein, associates with certain non-coding...

... analysis of the 28S bands from C as a percent of the lane 2 control. Our previous work demonstrates that in vitro transcribed U2 is selectively degraded by purified coilin, suggesting that coilin may take part in the 3′ end processing of this snRNA ( Broome and Hebert, 2012 ). Specifically...