... employ the Drosophila larval lymph gland (LG) to investigate the impact of genetic perturbation of cellular homeostasis on hematopoiesis. The LG consists of a posterior signaling center (PSC) – a stem cell niche that maintains medullary zone (MZ) prohemocytes, whereas the cortical zone (CZ) consists...

...James F. Clark; Philippe Soriano ABSTRACT FGF activation is known to engage canonical signals, including ERK/MAPK and PI3K/AKT, through various effectors including FRS2 and GRB2. Fgfr2 FCPG/FCPG mutants that abrogate canonical intracellular signaling exhibit a range of mild phenotypes...

...Pamela Mancini; Olga Ossipova; Sergei Y. Sokol ABSTRACT Coordinated polarization of cells in the tissue plane, known as planar cell polarity (PCP), is associated with a signaling pathway critical for the control of morphogenetic processes. Although the segregation of PCP components to opposite cell...

...Calvin Lam; Yanlei Li; Tim Landgraf; James Nieh ABSTRACT The function of the honey bee tremble dance and how it attracts signal receivers is poorly understood. We tested the hypothesis that tremble followers and waggle followers exhibit the same dance-following behavior. If correct, this could...

...Wen Zhang; John E. Lunn; Regina Feil; Yufei Wang; Jingjing Zhao; Hongxia Tao; Yanping Guo; Zhengyang Zhao ABSTRACT Trehalose-6-phosphate (Tre6P) is a precursor of trehalose, which is widespread in nature and greatly influences plant growth and development. Tre6P acts as a signal of carbon...

... retinal homeostasis through regulation of vascular permeability. Here we investigate the role of Tbdn expression on signaling components of retinal endothelial permeability to understand how Tbdn regulates the vasculature and supports retinal homeostasis. Tbdn knockdown-induced hyperpermeability...