... understand how signal transduction pathways regulate diverse vascular responses. The vascular endothelial growth factor (VEGF) family bind membrane-bound receptor tyrosine kinases (VEGFRs), which trigger multiple signal transduction pathways and diverse cellular responses. We evaluated whether the MAP3K...

... defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 2 (VEGFR2) regulate signal transduction and angiogenesis, but how signaling and proteolysis is regulated is not well understood. Here, we provide evidence that a pathway requiring the E1 ubiquitin...

... with primitive streak formation at E6.5. We have used transcriptome and marker gene analyses to describe the molecular etiology of the t w18 phenotype. We show that both WNT and Nodal signal transduction are impaired in the mutant epiblast, causing embryonic patterning defects and failure of primitive streak...

... by targeting SMXL6-clade proteins, but not BES1 or DELLA proteins, for degradation. BRC1 and PIN1 plausibly act downstream to regulate branching. Shoot branching Signal transduction Strigolactone Plant development is a continuous process that is modulated by multiple environmental stimuli. Many...

...Killeen S. Kirkconnell; Michelle T. Paulsen; Brian Magnuson; Karan Bedi; Mats Ljungman ABSTRACT Dynamic regulation of gene expression via signal transduction pathways is of fundamental importance during many biological processes such as cell state transitioning, cell cycle progression and stress...

... Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). Endothelium GEF GTPase Inflammation Signal transduction At the interface between the circulation and the underlying tissue, the endothelium plays a key role in controlling...