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Keywords: SPD-5
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Journal Articles

Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit

Stephen J. Enos, Martin Dressler, Beatriz Ferreira Gomes, Anthony A. Hyman, Jeffrey B. Woodruff
Journal: Biology Open
Biol Open (2018) 7 (1): bio029777.
https://doi.org/10.1242/bio.029777
Published: 12 January 2018
..., ∼25% of PCM persisted from one cell cycle into the next. Purified PP2A SUR-6 could dephosphorylate the major PCM scaffold protein SPD-5 in vitro . Our data suggest that PCM disassembly occurs through a combination of dephosphorylation of PCM components and force-driven fragmentation of the PCM...
View article titled, Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit
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Includes: Supplementary data
Journal Articles

Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation

Oliver Wueseke, David Zwicker, Anne Schwager, Yao Liang Wong, Karen Oegema, Frank Jülicher, Anthony A. Hyman, Jeffrey B. Woodruff
Journal: Biology Open
Biol Open (2016) 5 (10): 1431–1440.
https://doi.org/10.1242/bio.020990
Published: 2 September 2016
... (PCM). In Caenorhabditis elegans embryos, the mitotic PCM expands by Polo-like kinase 1 (PLK-1) phosphorylation-accelerated assembly of SPD-5 molecules into supramolecular scaffolds. However, how PLK-1 phosphorylation regulates SPD-5 assembly is not known. We found that a mutant version of SPD-5...
View article titled, Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing <span class="search-highlight">SPD</span>-<span class="search-highlight">5</span> toward an assembly-competent conformation
Open the PDF for Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing <span class="search-highlight">SPD</span>-<span class="search-highlight">5</span> toward an assembly-competent conformation in another window
Includes: Supplementary data