...Dan Zhang; Doina M. Mihai; Ilyas Washington ABSTRACT In the most prevalent retinal diseases, including Stargardt disease and age-related macular degeneration (AMD), byproducts of vitamin A form in the retina abnormally during the vitamin A cycle. Despite evidence of their toxicity, whether...

... mainly focused on the brain. However, little is known about the expression pattern of lhx9 during embryogenesis. Here, we detected lhx9 expression in zebrafish embryos using whole-mount in situ hybridization and found lhx9 expressed in heart, pectoral fin, and retina during their development in zebrafish...

... cues that converge on the mammalian target of rapamycin complex 1 (mTORC1). Here we demonstrate that mTORC1-signalling mediates multi-faceted roles during central nervous system development using the mouse retina as a model system. Downregulation of mTORC1-signalling in retinal progenitor cells...

... Siah is active during early eye development ( Fig. 2 C). When examining distribution of the GFP-VSP signal we did not detect any regional concentration of siah activity, rather the entire retina appeared to contain active Siah. As control, treatment with MG132 restored GFP-VSP signal throughout the eye...

... organotypic ex vivo retinal hypoxia model. A chamber was developed in which rat retinal explants were incubated for different hypoxia durations. Afterwards, the retinas were adjusted to normal air and incubated for 24, 48 or 72 h under standard conditions. To analyze the retinal explants, and in particular...

...Jörg Steinfeld; Ichie Steinfeld; Alexander Bausch; Nicola Coronato; Meggi-Lee Hampel; Heike Depner; Paul G. Layer; Astrid Vogel-Höpker ABSTRACT In vertebrates, the retinal pigment epithelium (RPE) and photoreceptors of the neural retina (NR) comprise a functional unit required for vision. During...

... survivors typically suffer long-term injuries not only to the lungs, but also to the brain and retina. However, currently it is not clear whether the brain and retinal injuries in these newborns are related only to their prematurity, or also to BPD. We investigated whether the hyperoxia known to cause...

..., is posttranslationally glutamylated at its C-terminus and is a target of GT335. Retina RPGR Cilia Glutamylation GT335 Retinitis pigmentosa (RP) is a group of genetically and clinically heterogeneous disorders of the eye. RP is characterized by night blindness due to the loss of rod photoreceptors...

... UV permissive cornea and lens. Seals like other carnivores have a tapetum lucidum (TL) reflecting light back through the retina increasing sensitivity. The TL in this seal is unusual being white and covering almost the entire retina unlike that in other carnivores. Spectral reflectance from its...

..., or 6 weeks of administration of Dox diet. Eye sections were analyzed histologically as described previously ( Wall et al., 2004 ; Gendron et al., 2010 ) to map the progression of choroid-retinal pathology. Mouse retinae were surgically dissected from the sclera, vitreous and other ocular tissues under...

...Kimberly A. Wong; Michael Trembley; Syafiq Abd Wahab; Andrea S. Viczian Retina formation requires the correct spatiotemporal patterning of key regulatory factors. While it is known that repression of several signaling pathways lead to specification of retinal fates, addition of only Noggin, a known...

... has focused on cell cycle, DNA repair and cancer in cultured cells, but data on the inter-dependence of separate components of the SUMO pathway in highly specialized tissues, such as the retina, is still scanty. Nonetheless, several retinal transcription factors (TFs) relevant for cone and rod fate...

... of Top2b, especially during postnatal neural development, remains to be determined. Using both the constitutive and retina-specific knockout mouse models, we showed that Top2b deficiency resulted in delayed neuronal differentiation, degeneration of the plexiform layers and outer segment of photoreceptors...

.../licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Polarity Neuroepithelia Retina Crumbs Zebrafish Epithelial tissues are built from cells with marked polarity, manifested by the polarised...

... (VSMCs) and pericytes, and that Msx2 lacZ is also expressed in VSMCs as well as in a few endothelial cells (ECs). The mouse retina and choroid are two highly vascularized tissues. Vessel alterations in the retina are associated with several human diseases and the retina has been intensely used...

...Brian G. Ballios; Laura Clarke; Brenda L. K. Coles; Molly S. Shoichet; Derek Van Der Kooy Summary Self-renewing, multipotential retinal stem cells (RSCs) reside in the pigmented ciliary epithelium of the peripheral retina in adult mammals. RSCs can give rise to rhodopsin positive-cells, which can...