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Keywords: Rapamycin
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Journal Articles

The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts

Vedad Delic, Kenyaria Noble, Sandra Zivkovic, Tam-Anh Phan, Christian Reynes, Yumeng Zhang, Oluwakemi Phillips, Charles Claybaker, Yen Ta, Vinh B. Dinh, Josean Cruz, Tomas A. Prolla, Patrick C. Bradshaw
Journal: Biology Open
Biol Open (2018) 7 (11): bio033852.
https://doi.org/10.1242/bio.033852
Published: 16 November 2018
...-containing media, POLG exonuclease-deficient MEFs showed decreased oxygen consumption compared to controls. Increased AMP-activated protein kinase (AMPK) signaling and decreased mammalian target of rapamycin (mTOR) signaling delayed aging and influenced mitochondrial function. Therefore, the effects of 5...
View articletitled, The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
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Includes: Supplementary data