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Keywords: RGCs
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Journal Articles

Reduced mTORC1-signalling in retinal progenitor cells leads to visual pathway dysfunction

Iwan Jones, Anna-Carin Hägglund, Leif Carlsson
Journal: Biology Open
Biol Open (2019) 8 (8): bio044370.
https://doi.org/10.1242/bio.044370
Published: 1 August 2019
... . 10.1074/jbc.M116.744482 The distinct spatial pattern of Rptor -ablation observed in Lhx2-Cre:Rptor f/f mice fortuitously provided an opportunity to investigate how contrasting reductions in mTORC1-signalling influenced RGC neurogenesis [embryonic day (E) 12.5] and radial migration (E16.5...
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Includes: Supplementary data
Journal Articles

Establishment of a retinal hypoxia organ culture model

S. Schnichels, M. Blak, J. Hurst, T. Dorfi, K. U. Bartz-Schmidt, F. Ziemssen, M. S. Spitzer, M. Schultheiss
Journal: Biology Open
Biol Open (2017) 6 (7): 1056–1064.
https://doi.org/10.1242/bio.025429
Published: 15 July 2017
... the retinal ganglion cells (RGC) immunohistology, western blot and optical coherence tomography (OCT) measurements were performed. To compare our model to a standardized degeneration model, additional retinal explants were treated with 0.5 and 1 mM glutamate. Depending on hypoxia duration and incubation time...
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