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Keywords: Proliferation
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Journal Articles
Journal Articles
Biol Open (2024) 13 (1): bio059919.
Published: 22 January 2024
.... Proliferation was also reduced due potentially to a blockage in the G1 phase of the cell cycle or an induction of quiescence. Mass spectrometry analysis confirmed alterations in several proteins associated with differentiation and the cell cycle. In addition, overexpression of ASCL2 enhanced resistance...
Includes: Supplementary data
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Biol Open (2020) 9 (11): bio053447.
Published: 12 November 2020
... (IHC) showed that MIF is highly expressed in the epithelium and that MIF and PCNA expression levels are higher in BPH samples than in control. CCK8 and flow cytometry assays showed that recombinant human MIF (rMIF) promoted the proliferation of BPH-1 and PWR-1E cells, while ISO-1 partially reversed...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (3): bio049478.
Published: 11 March 2020
... was significantly reduced. In addition, the FOXF2 expression was negatively related to the miR-96-5p level in OSCC tissues. Furthermore, downregulation of miR-96-5p obviously restrained OSCC cell proliferation, invasion and EMT. We confirmed that miR-96-5p could directly target FOXF2 by luciferase reporter assay...
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Journal Articles
Biol Open (2019) 8 (8): bio042937.
Published: 1 August 2019
..., bioinformatic analysis demonstrated that miRNA-138 directly targeted HIF1α. We found that the introduction of pre-miRNA-138 sequences to A375 cells reduced HIF1α mRNA expression and suppressed cell proliferation, migration and invasion. Overexpression of miRNA-138 or inhibition of HIF1α significantly suppressed...
Journal Articles
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Journal Articles
Biol Open (2017) 6 (8): 1123–1129.
Published: 12 June 2017
... in proliferation and invasion in trophoblast cell lines (BeWo and JAR). Small hairpin RNAs targeting Notch2/Notch3 and Notch2/Notch3-overexpression vectors were designed, constructed and transfected into BeWo and JAR cells. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were...
Journal Articles
Biol Open (2017) 6 (3): 311–316.
Published: 28 November 2016
...)-2,5-diphenyltetrazolium bromide] and BrdU (5-bromo-2-deoxyuridine) incorporation assays were used to evaluate the cell proliferation of GBM cells. Wound-healing and transwell assays were preformed to analyze GBM cell migration and invasion, respectively. The results suggested that parecoxib inhibits...
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Journal Articles
Journal Articles
Biol Open (2016) 5 (6): 669–677.
Published: 16 May 2016
... of miR-93 promoted the proliferation, migration and invasion of glioma cells, and that miR-93 was involved in the regulation of cell cycle progression by mediating the protein levels of P21, P27, P53 and Cyclin D1. P21 was further identified as a direct target of miR-93. Knockdown of P21 attenuated...
Journal Articles
Journal Articles
Biol Open (2014) 3 (9): 821–831.
Published: 22 August 2014
... and reproduction in any medium provided that the original work is properly attributed. PDCD2 Mouse embryo Cell cycle Proliferation ESCs p53 PDCD2 (programmed cell death protein 2) is a highly conserved, zinc finger MYND domain-containing protein of unknown molecular function. PDCD2 RNA...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2013) 2 (8): 822–828.
Published: 20 June 2013
... Hippo pathway activity to control the expression of cyclin E and Myc to promote cell proliferation, as well as the expression of bantam miRNA and DIAP1 to inhibit cell death. Here we present evidence that the Hippo pathway acts via Yorkie and p53 to control the expression of the proapoptotic gene reaper...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (5): 515–524.
Published: 10 April 2013
...) primordia during early embryonic brain development. To examine roles of Fgf22 in midbrain development, we analyzed fgf22 knockdown embryos. The fgf22 morphants were defective in proper formation of the MHB constriction and the midbrain. The knockdown of fgf22 caused decreased cell proliferation...
Includes: Supplementary data