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Keywords: Proliferation
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Journal Articles
Biol Open (2022) 11 (1): bio059049.
Published: 7 February 2022
... cell immunotherapy. For successful immunotherapy, it is important both to characterise Vγ9Vδ2 T cell proliferation and optimise the assessment of their cytotoxic potential, which is the aim of this study. We found that supplementation with freshly thawed human serum potentiated Vγ9Vδ2 T cell...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (12): bio051904.
Published: 21 December 2020
... proliferator-activated receptor β (PPARβ) was measured by RT-qPCR assay. The protein levels of PPARβ, α-SMA, Vimentin, COL1A, cyclin D1, bcl-2, and bax were detected by western blot assay. The effect of miR-9-5p and PPARβ on HS fibroblasts proliferation and apoptosis were detected by cell counting kit-8 (CCK-8...
Journal Articles
Biol Open (2020) 9 (11): bio053447.
Published: 12 November 2020
... (IHC) showed that MIF is highly expressed in the epithelium and that MIF and PCNA expression levels are higher in BPH samples than in control. CCK8 and flow cytometry assays showed that recombinant human MIF (rMIF) promoted the proliferation of BPH-1 and PWR-1E cells, while ISO-1 partially reversed...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (3): bio049478.
Published: 11 March 2020
... was significantly reduced. In addition, the FOXF2 expression was negatively related to the miR-96-5p level in OSCC tissues. Furthermore, downregulation of miR-96-5p obviously restrained OSCC cell proliferation, invasion and EMT. We confirmed that miR-96-5p could directly target FOXF2 by luciferase reporter assay...
Journal Articles
Biol Open (2020) 9 (2): bio046854.
Published: 7 February 2020
... mechanisms remain unexplored. In our study, we found that PP2 could remarkably suppress the proliferation of two liver cancer cell lines, HepG2 and BEL7402, resulting in significant cell death. Besides, low doses of PP2 have displayed properties that inhibit cellular motility and invasion of liver cancer...
Journal Articles
Biol Open (2019) 8 (8): bio042937.
Published: 1 August 2019
..., bioinformatic analysis demonstrated that miRNA-138 directly targeted HIF1α. We found that the introduction of pre-miRNA-138 sequences to A375 cells reduced HIF1α mRNA expression and suppressed cell proliferation, migration and invasion. Overexpression of miRNA-138 or inhibition of HIF1α significantly suppressed...
Journal Articles
Biol Open (2019) 8 (6): bio039248.
Published: 6 June 2019
.... Here, we report that Suppressor of Fused (Sufu) plays a critical role in the establishment of the V-SVZ at early neonatal stages by controlling the proliferation of distinct subpopulations of stem/precursor cells. Conditional deletion of Sufu in radial glial progenitor cells (RGCs) at E13.5 resulted...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (5): bio033670.
Published: 14 May 2018
... AKT and p38 MAPK pathways. Moreover, SGE regulates the expression of myoD1, myogenin and MCH2b at the beginning of differentiation. C2C12 cells 1α,25(OH)2D3-glycosides P38 MAPK AKT MyoD1 Myogenin MHC2b Proliferation The biologically active form of vitamin D is 1α,25...
Journal Articles
Biol Open (2017) 6 (8): 1123–1129.
Published: 12 June 2017
... in proliferation and invasion in trophoblast cell lines (BeWo and JAR). Small hairpin RNAs targeting Notch2/Notch3 and Notch2/Notch3-overexpression vectors were designed, constructed and transfected into BeWo and JAR cells. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were...
Journal Articles
Biol Open (2017) 6 (3): 311–316.
Published: 28 November 2016
...)-2,5-diphenyltetrazolium bromide] and BrdU (5-bromo-2-deoxyuridine) incorporation assays were used to evaluate the cell proliferation of GBM cells. Wound-healing and transwell assays were preformed to analyze GBM cell migration and invasion, respectively. The results suggested that parecoxib inhibits...
Journal Articles
Biol Open (2016) 5 (9): 1260–1265.
Published: 19 August 2016
...′-untranslated region (3′-UTR) of SMO mRNA were predicted to have complementary binding regions. Accordingly, we inferred that miR-20a might act as a regulator of SMO, and regulate proliferation, differentiation and apoptosis in P19 cells. We determined the expression of miR-20a, SMO and marker proteins...
Journal Articles
Biol Open (2016) 5 (6): 794–800.
Published: 16 May 2016
... of this study was to investigate the biological roles of leptin and the mechanisms attributed to its action in non-small cell lung cancer (NSCLC) cell lines. The expression of leptin was measured by quantitative real-time PCR and western blot in seven NSCLC cell lines. Proliferation and apoptosis of NSCLC cells...
Journal Articles
Biol Open (2016) 5 (6): 669–677.
Published: 16 May 2016
... of miR-93 promoted the proliferation, migration and invasion of glioma cells, and that miR-93 was involved in the regulation of cell cycle progression by mediating the protein levels of P21, P27, P53 and Cyclin D1. P21 was further identified as a direct target of miR-93. Knockdown of P21 attenuated...
Journal Articles
Biol Open (2014) 3 (12): 1164–1172.
Published: 13 November 2014
... and tumor-angiogenesis. Herein, we tested the involvement of classical cannabinoid receptors (CBRs) and the Ca 2+ -channel transient receptor potential vanilloid 1 (TRPV1) on cellular AEA uptake and its effect on endothelial cell proliferation and network-formation. Uptake of the fluorescence-labeled...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (9): 821–831.
Published: 22 August 2014
... and reproduction in any medium provided that the original work is properly attributed. PDCD2 Mouse embryo Cell cycle Proliferation ESCs p53 PDCD2 (programmed cell death protein 2) is a highly conserved, zinc finger MYND domain-containing protein of unknown molecular function. PDCD2 RNA...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (9): 941–951.
Published: 26 July 2013
... of prostate cancer development, such as cell growth. However, the molecular nature of those K + channels implicated in prostate cancer cell proliferation and the mechanisms through which they control proliferation are still unknown. This study uses pharmacological, biophysical and molecular approaches to show...
Journal Articles
Biol Open (2013) 2 (8): 822–828.
Published: 20 June 2013
... Hippo pathway activity to control the expression of cyclin E and Myc to promote cell proliferation, as well as the expression of bantam miRNA and DIAP1 to inhibit cell death. Here we present evidence that the Hippo pathway acts via Yorkie and p53 to control the expression of the proapoptotic gene reaper...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (5): 515–524.
Published: 10 April 2013
...) primordia during early embryonic brain development. To examine roles of Fgf22 in midbrain development, we analyzed fgf22 knockdown embryos. The fgf22 morphants were defective in proper formation of the MHB constriction and the midbrain. The knockdown of fgf22 caused decreased cell proliferation...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (8): 723–730.
Published: 12 June 2012
... including the regulation of cell proliferation, migration, differentiation, and survival. It is currently being actively targeted therapeutically using different approaches. We have used human endothelial cells as a model system to compare the effects of inhibiting FAK through several different approaches...
Includes: Supplementary data