... possible cause of shortcomings may be that model organisms used to characterize basic vertebrate embryology ( Xenopus , zebrafish, chick) may employ molecular mechanisms for stem cell specification that are not conserved in humans, a prominent example being the specification of primordial germ cells (PGCs...

...Jennifer Jones; Paul M. Macdonald ABSTRACT Primordial germ cells (PGCs) form at the posterior pole of the Drosophila embryo, and then migrate to their final destination in the gonad where they will produce eggs or sperm. Studies of the different stages in this process, including assembly of germ...

... of the DS-3′ to mRNA is known to induce primordial germ cell (PGC)-specific expression and reduce the stability in somatic cells of mRNA in Xenopus laevis . At first, we inserted the X. tropicalis DS-3′ downstream of the EGFP termination codon and confirmed that the EGFP expression was specifically detected...

...Aliaksandr Dzementsei; David Schneider; Andreas Janshoff; Tomas Pieler Summary The directional migration of primordial germ cells (PGCs) to the site of gonad formation is an advantageous model system to study cell motility. The embryonic development of PGCs has been investigated in different animal...

...Ana De Melo Bernardo; Kaylee Sprenkels; Gabriela Rodrigues; Toshiaki Noce; Susana M. Chuva De Sousa Lopes Summary During gastrulation, chicken primordial germ cells (PGCs) are present in an extraembryonic region of the embryo from where they migrate towards the genital ridges. This is also observed...