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Keywords: Polarity
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Journal Articles
Biol Open (2022) 11 (7): bio059408.
Published: 25 July 2022
...Mark J. Khoury; David Bilder ABSTRACT The compartmentalized domains of polarized epithelial cells arise from mutually antagonistic actions between the apical Par complex and the basolateral Scrib module. In Drosophila , the Scrib module proteins Scribble (Scrib) and Discs-large (Dlg) are required...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (2): bio047555.
Published: 11 February 2020
... of paramount importance. The maintenance of proper vision depends, among other factors, on the function of genes controlling apico-basal polarity. In fact, mutations in polarity genes are linked to retinal degeneration in several species, including human. Here we describe a novel zebrafish crb2b allele ( crb2b...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (1): bio039552.
Published: 17 January 2019
...Raju Baskar; Anna Bakrhat; Uri Abdu ABSTRACT The polarized organization of the Drosophila oocyte can be visualized by examining the asymmetric localization of mRNAs, which is supported by networks of polarized microtubules (MTs). In this study, we used the gene forked , the putative Drosophila...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (11): bio036632.
Published: 31 October 2018
... changes in the developing zebrafish retina is missing. Here, we performed an in-depth characterisation of four of the five PRC subtypes of the zebrafish retina between 51 and 120 h post fertilisation, including quantification of the size of different compartments, localisation of polarity proteins...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (1): bio031435.
Published: 26 January 2018
...Shradha Das; Elisabeth Knust ABSTRACT Epithelia are highly polarised tissues and several highly conserved polarity protein complexes serve to establish and maintain polarity. The transmembrane protein Crumbs (Crb), the central component of the Crb protein complex, is required, among others...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (10): 1502–1515.
Published: 31 August 2017
.... , Baird , M. A. , Davidson , M. W. , Waterman , C. M. and Myers , K. A. ( 2014 ). Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells . J. Cell Biol.   206 , 97 - 112 . 10.1083/jcb.201401063 Braun , A. , Caesar , N. M. , Dang...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (3): 358–364.
Published: 6 February 2017
... and polarity of the chondrocyte. We used in vitro and in vivo models of Smad4 deficiency in chondrocytes to test the hypothesis that deregulated TGFβ signaling leads to aberrant extracellular matrix production and loss of chondrocyte polarity. Specifically, we evaluated growth plate chondrocyte polarity...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (1): 20–31.
Published: 23 December 2015
...Domenico F. Galati; David S. Abuin; Gabriel A. Tauber; Andrew T. Pham; Chad G. Pearson ABSTRACT Multi-ciliated cells (MCCs) use polarized fields of undulating cilia (ciliary array) to produce fluid flow that is essential for many biological processes. Cilia are positioned by microtubule scaffolds...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (4): 528–541.
Published: 13 March 2015
...Jaffer Shahab; Manu D. Tiwari; Mona Honemann-Capito; Michael P. Krahn; Andreas Wodarz Apico-basal polarity is the defining characteristic of epithelial cells. In Drosophila , apical membrane identity is established and regulated through interactions between the highly conserved Par complex (Bazooka...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (3): 301–311.
Published: 6 February 2015
... in morphogenetic consequences in the syncytial division cycle. These included inhibition of metaphase furrow ingression, randomization of proteins normally polarized to intercap PM and disruption of the diffusion barrier separating PM domains above nuclei. Based on these findings, we propose that cell cycle...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (11): 1270–1278.
Published: 16 October 2013
...Pankhuri Vyas; Aditi Singh; Prayag Murawala; Jomon Joseph Summary Par polarity complex, consisting of Par3, Par6, and aPKC, plays a conserved role in the establishment and maintenance of polarization in diverse cellular contexts. Recent reports suggest that Dishevelled (Dvl), a cytoplasmic mediator...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (12): 1313–1320.
Published: 23 September 2013
...Timm Haack; Dan T. Bergstralh; Daniel St Johnston Summary The Drosophila follicular epithelium, which surrounds developing egg chambers, is a well-established model for studying epithelial polarity because it is continuously generated from adult stem cells, making it easy to generate homozygous...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2013) 2 (9): 867–871.
Published: 1 July 2013
...Marta Luz; Elisabeth Knust Summary Development of epithelial cell polarity is a highly dynamic process, and often established by the sequential recruitment of conserved protein complexes, such as the Par or the Crumbs (Crb) complex. However, detailed insights into the refinement of polarity...