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Keywords: Planar cell polarity
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Journal Articles
Biol Open (2018) 7 (11): bio033001.
Published: 2 November 2018
.... Among these co-receptors are several with structural homology to receptor tyrosine kinases, including Ror, PTK7, Ryk and MUSK. In vertebrates, Ror-2 and PTK7 are important regulators of planar cell polarity (PCP). By contrast, PCP phenotypes were not reported for mutations in off-track ( otk ) and off...
Includes: Supplementary data
Journal Articles
Journal Articles
Biol Open (2016) 5 (3): 229–236.
Published: 10 February 2016
...Katherine A. Sharp; Jeffrey D. Axelrod ABSTRACT Planar cell polarity signaling directs the polarization of cells within the plane of many epithelia. While these tissues exhibit asymmetric localization of a set of core module proteins, in Drosophila , more than one mechanism links the direction...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (6): 722–730.
Published: 14 July 2015
...Olga Ossipova; Kyeongmi Kim; Sergei Y. Sokol The vertebrate neural tube forms as a result of complex morphogenetic movements, which require the functions of several core planar cell polarity (PCP) proteins, including Vangl2 and Prickle. Despite the importance of these proteins for neurulation...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (9): 861–870.
Published: 4 September 2014
...Chunqiao Liu; Chen Lin; Chun Gao; Helen May-Simera; Anand Swaroop; Tiansen Li ABSTRACT Planar cell polarity (PCP) signaling plays a critical role in tissue morphogenesis. In mammals, disruption of three of the six “core PCP” components results in polarity-dependent defects with rotated cochlear...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (10): 1007–1012.
Published: 14 August 2013
..., common sensors of shear, and thus must use an alternative mechanism of sensing the strength and direction of flow. In our experiments in microfluidic perfusion chambers, confluent ECs developed planar cell polarity at a rate proportional to the shear stress. The location of Golgi apparatus...
Includes: Multimedia, Supplementary data
Journal Articles
Biol Open (2012) 1 (5): 498–505.
Published: 12 April 2012
...Ivana Mirkovic; Serhiy Pylawka; A. J. Hudspeth Summary In addition to their ubiquitous apical-basal polarity, many epithelia are also polarized along an orthogonal axis, a phenomenon termed planar cell polarity (PCP). In the mammalian inner ear and the zebrafish lateral line, PCP is revealed...
Includes: Multimedia, Supplementary data