... evidence that once Mtb is ingested by the macrophage, Cpn60.2 is able to detach from the bacterial surface and crosses the phagosomal membrane towards mitochondria organelles. Once there, Cpn60.2 interacts with host mortalin, a member of the HSP 70 gene family that contributes to apoptosis modulation...

...Kanin Salao; Lele Jiang; Hui Li; Vicky W.-W. Tsai; Yasmin Husaini; Paul M. G. Curmi; Louise J. Brown; David A. Brown; Samuel N. Breit ABSTRACT Intracellular chloride channel protein 1 (CLIC1) participates in inflammatory processes by regulating macrophage phagosomal functions such as pH...