... intracellular transport of neurotransmitter vesicles, loss of centrosome activity could contribute to functional deficits and neuronal cell death in Parkinson's disease. In addition, we provide evidence that many cell types, including dopaminergic neurons, cannot form cilia when aggresomes are present, which...

...Smijin K. Soman; Michal Bazała; Marcus Keatinge; Oliver Bandmann; Jacek Kuznicki ABSTRACT The loss of dopaminergic neurons (DA) is a pathological hallmark of sporadic and familial forms of Parkinson's disease (PD). We have previously shown that inhibiting mitochondrial calcium uniporter ( mcu...

...Susann Lehmann; Samantha H. Y. Loh; L. Miguel Martins ABSTRACT Familial forms of Parkinson's disease (PD) caused by mutations in PINK1 are linked to mitochondrial impairment. Defective mitochondria are also found in Drosophila models of PD with pink1 mutations. The co-enzyme nicotinamide adenine...

...Yusuke Toyoda; Cihan Erkut; Francisco Pan-Montojo; Sebastian Boland; Martin P. Stewart; Daniel J. Müller; Wolfgang Wurst; Anthony A. Hyman; Teymuras V. Kurzchalia Parkinson's disease is associated with mitochondrial decline in dopaminergic neurons of the substantia nigra . One of the genes linked...