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Keywords: Pancreatic cancer
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Journal Articles

FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling

Open Access
Ying Chen, Peihui Liu, Di Shen, Han Liu, Lepeng Xu, Jian Wang, Daguang Shen, He Sun, Hongkui Wu
Journal: Biology Open
Biol Open (2020) 9 (2): bio048462.
https://doi.org/10.1242/bio.048462
Published: 7 February 2020
...Ying Chen; Peihui Liu; Di Shen; Han Liu; Lepeng Xu; Jian Wang; Daguang Shen; He Sun; Hongkui Wu ABSTRACT FAM172A, as a newly discovered gene, is little known in cancer development, especially in pancreatic cancer (PC). We investigated the potential role and molecular mechanism of FAM172A...
View articletitled, FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling
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Journal Articles

MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1α) in the tumor microenvironments

Open Access
Yebin Lu, Niandong Ji, Wei Wei, Weijia Sun, Xuejun Gong, Xitao Wang
Journal: Biology Open
Biol Open (2017) 6 (2): 252–259.
https://doi.org/10.1242/bio.021774
Published: 9 January 2017
...Yebin Lu; Niandong Ji; Wei Wei; Weijia Sun; Xuejun Gong; Xitao Wang ABSTRACT MicroRNAs regulate most protein-coding genes, including genes important in cancer and other diseases. In this study, we demonstrated that the expression of miR-142 could be significantly suppressed in pancreatic cancer...
View articletitled, MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1α) in the tumor microenvironments
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Journal Articles

Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis

Open Access
Nelson S. Yee, Abid A. Kazi, Qin Li, Zhaohai Yang, Arthur Berg, Rosemary K. Yee
Journal: Biology Open
Biol Open (2015) 4 (4): 507–514.
https://doi.org/10.1242/bio.20137088
Published: 13 March 2015
...Nelson S. Yee; Abid A. Kazi; Qin Li; Zhaohai Yang; Arthur Berg; Rosemary K. Yee Our previous studies in zebrafish development have led to identification of the novel roles of the transient receptor potential melastatin-subfamily member 7 (TRPM7) ion channels in human pancreatic cancer. However...
View articletitled, Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis
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Includes: Supplementary data
Journal Articles

Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer

Open Access
Nelson S. Yee, Weiqiang Zhou, Stephen G. Chun, I-Chau Liang, Rosemary K. Yee
Journal: Biology Open
Biol Open (2012) 1 (4): 295–307.
https://doi.org/10.1242/bio.2012539
Published: 10 February 2012
... are required for exocrine pancreatic epithelial proliferation during morphogenesis in zebrafish. We aim to test the hypothesis that Hdacs and Polr3 cooperatively control exocrine pancreatic growth, and combined inhibition of HDACs and POLR3 produces enhanced growth suppression in pancreatic cancer...
View articletitled, Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer
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Includes: Supplementary data