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Keywords: PKA
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Journal Articles

High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

Open Access
Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Che
Journal: Biology Open
Biol Open (2021) 10 (5): bio055012.
https://doi.org/10.1242/bio.055012
Published: 20 May 2021
... role of Smad3, ezrin, and protein kinase A (PKA) in NADPH oxidase (Nox4) expression, reactive oxidative species (ROS) production, and apoptosis in HG-treated podocytes. A human podocyte cell line was cultured and differentiated, then treated with 30 mM HG. Apoptosis and intracellular ROS levels were...
View articletitled, High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
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Journal Articles

The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing

Open Access
Arum Han, Balaji Bandyopadhyay, Priyamvada Jayaprakash, Ingrid Lua, Divya Sahu, Mei Chen, David T. Woodley, Wei Li
Journal: Biology Open
Biol Open (2012) 1 (12): 1169–1177.
https://doi.org/10.1242/bio.20122246
Published: 20 September 2012
..., Protein Kinase Array allowed us to identify the protein kinase A (PKA) as a specific downstream effector of R-Smads in dermal fibroblasts. Activation of PKA alone blocked PDGF-bb-induced dermal fibroblast migration, just like TGFβ3. Downregulation of PKA's catalytic subunit nullified the anti-motility...
View articletitled, The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing
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Includes: Supplementary data