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Keywords: PKA
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Journal Articles
Biol Open (2021) 10 (5): bio055012.
Published: 20 May 2021
... role of Smad3, ezrin, and protein kinase A (PKA) in NADPH oxidase (Nox4) expression, reactive oxidative species (ROS) production, and apoptosis in HG-treated podocytes. A human podocyte cell line was cultured and differentiated, then treated with 30 mM HG. Apoptosis and intracellular ROS levels were...
Journal Articles
Biol Open (2012) 1 (12): 1169–1177.
Published: 20 September 2012
..., Protein Kinase Array allowed us to identify the protein kinase A (PKA) as a specific downstream effector of R-Smads in dermal fibroblasts. Activation of PKA alone blocked PDGF-bb-induced dermal fibroblast migration, just like TGFβ3. Downregulation of PKA's catalytic subunit nullified the anti-motility...
Includes: Supplementary data