...Paul Kopesky; Kerstin Tiedemann; Dahlia Alkekhia; Christoph Zechner; Bjorn Millard; Birgit Schoeberl; Svetlana V. Komarova ABSTRACT Osteoclasts are responsible for bone destruction in degenerative, inflammatory and metastatic bone disorders. Although osteoclastogenesis has been well-characterized...

... osteoclast differentiation. Surprisingly, small increases in pyruvate (1–2 mM above basal levels) augmented osteoclastogenesis in vitro and in vivo , while larger increases were not effective in vitro . Osteoclast differentiation increased cell mitochondrial activity and ATP levels, which were further...