.... Summary: Ub KEKS is a new universal post-translational modification which brings a new depth in the ubiquitin regulation system. Here, we explore its impact on nucleolar composition, structures and functions. Ub KEKS Data-independent acquisition (DIA) Nucleolus Post-translational modification...

... smaller, nucleolus-enriched fragments. We hypothesize that the fragments derived from scaRNA 2, 9 and 17 form regulatory RNPs that influence the level of modifications within rRNA by altering small nucleolar RNP (snoRNP) activity. Here we show that external factors such as DNA damaging agents can alter...

... heterogeneity is variation in rRNA modification by methylation and pseudouridylation. Our work provides additional evidence for the regulation of snoRNP activity by regRNPs, which alters levels of methylation. Cajal body Nucleolus snoRNPs An exciting emerging concept is that of ribosome...

... Cajal body-specific RNP (scaRNP), which contributes to the biogenesis of small nuclear RNPs (snRNPs) that are central components of the spliceosome. Three scaRNAs are internally processed, generating stable nucleolus-enriched RNAs of unknown function. Here, we provide data that show that these RNAs...