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Keywords: Nucleolus
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Journal Articles
Biol Open (2018) 7 (9): bio037101.
Published: 27 September 2018
... smaller, nucleolus-enriched fragments. We hypothesize that the fragments derived from scaRNA 2, 9 and 17 form regulatory RNPs that influence the level of modifications within rRNA by altering small nucleolar RNP (snoRNP) activity. Here we show that external factors such as DNA damaging agents can alter...
Journal Articles
Biol Open (2018) 7 (8): bio036095.
Published: 10 August 2018
... guide RNA decreases G3923 methylation by 71% (n=5, *P=0.002). A 2.1-fold increase in G3923 methylation is observed after scaRNA2 knockdown compared to control 2 (n=4, *P=0.002). We next evaluated the potential of the nucleolus-enriched fragment derived from scaRNA2 [mgU2-61 (regRNP2) ( Fig. 1...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (9): 1342–1354.
Published: 14 August 2017
... Cajal body-specific RNP (scaRNP), which contributes to the biogenesis of small nuclear RNPs (snRNPs) that are central components of the spliceosome. Three scaRNAs are internally processed, generating stable nucleolus-enriched RNAs of unknown function. Here, we provide data that show that these RNAs...
Includes: Supplementary data