... cells. It might be due to the fact that we were able to analyse only mutant cells of flies shifted to 29°C where they display the weakest, but the only analysable phenotype. However, it has recently been reported that loss of vps4 function does not cause uncontrolled activation of Notch signalling...

...Shohei Mikami; Mizuki Nakaura; Atsuo Kawahara; Takamasa Mizoguchi; Motoyuki Itoh ABSTRACT The Mindbomb E3 ubiquitin protein ligase (Mib) family of proteins, Mib1 and Mib2, are RING finger ubiquitin ligases that share specific substrates. Mib1 is known to play essential roles in Notch signalling...

...Beatriz P. San Juan; Irene Andrade-Zapata; Antonio Baonza Summary The Notch signalling pathway plays an essential role in the intricate control of cell proliferation and pattern formation in many organs during animal development. In addition, mutations in most members of this pathway are well...