... to tackle immune challenges and tailor developmental diversity. Hematopoiesis ESCRT Lineage choice Notch signaling Ubiquitin accumulation Lamellocytes Cargo sorting Non-canonical function of ESCRT SERB http://dx.doi.org/10.13039/501100001843 EMR/2016/000641 JC Bose JCB...

...Michelle A. Urman; Nimmy S. John; Tyler Jung; ChangHwan Lee ABSTRACT A major factor driving stem cell decline is stem cell niche aging, but its molecular mechanism remains elusive. We use the Caenorhabditis elegans distal tip cell (DTC), the mesenchymal niche that employs Notch signaling...

..., we find a mutant, stum 9-3 , affecting the proliferation and differentiation of Drosophila adult ISCs in a forward genetic screen for factors regulating the proliferation and differentiation ISCs. stum 9-3 acts through the conserved Notch signaling pathway, upstream of the S2 cleavage of the Notch...

... to maintain GSCs relies on Dally expression. Combining yeast and fruit fly genetics, we illustrate that Dally is under the transcriptional control of Notch signaling via the transcription factor Su(H). Further, we assayed human glypicans and disease-associated variants in Drosophila ovary, which can serve...

...Mina Azimi; Nadean L. Brown ABSTRACT Notch signaling regulates a multitude of cellular processes. During ocular lens development this pathway is required for lens progenitor growth, differentiation and maintenance of the transition zone. After ligand-receptor binding, the receptor proteins...

... transcription. Genetic interaction experiments identified that PP4 likely promotes Notch signaling within the nucleus of the Notch-receiving cell. Although the PP4 complex is implicated in various cellular processes, its role in the regulation of Wg and Notch pathways was previously uncharacterized. Our study...