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Keywords: Nodal
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Journal Articles
Biol Open (2021) 10 (2): bio051797.
Published: 25 February 2021
... precursors of the brain and the gastrula organizer. Previous findings suggested that the BCNE behaves as a homogeneous cell population that only depends on nuclear β-catenin activity but does not require Nodal and later segregates into its descendants during gastrulation. In contrast to previous findings, in...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (6): bio032656.
Published: 07 June 2018
... display enhanced invasion in the rhombencephalon of the chick embryo. In addition to driving neural crest migration in the zebrafish embryo, the agonists BMP-2, BMP-7 and nodal induce EMT/invasion in radial growth phase melanoma cells and in human melanocytes in skin reconstructs. Blocking either BMP or...
Journal Articles
Biol Open (2012) 1 (9): 874–883.
Published: 09 July 2012
...) have been shown to result in holoprosencephaly, leading to our hypothesis that Cripto is the key GPI anchored protein whose altered function results in an HPE-like phenotype. Cripto is an obligate Nodal co-factor involved in TGF β signaling, and we show that TGF β signaling is reduced both in vitro and...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (3): 208–219.
Published: 19 January 2012
... endoderm (XEN) stem cells have a particular advantage over other heart-inducing cell lines in that they can easily be derived from both wild type and mutant mouse blastocysts. Here we describe the first isolation of a Nodal mutant XEN stem cell line. Nodal −/− XEN cell lines were not isolated at expected...
Includes: Multimedia, Supplementary data