...Yan Wang; Roger Lopez-Bellido; Xiaojiao Huo; Annemieke Kavelaars; Michael J. Galko ABSTRACT Early phase diabetes is often accompanied by pain sensitization. In Drosophila , the insulin receptor ( InR ) regulates the persistence of injury-induced thermal nociceptive sensitization. Whether Drosophila...

...Barry Magee; Robert W. Elwood ABSTRACT Insights into the potential for pain may be obtained from examination of behavioural responses to noxious stimuli. In particular, prolonged responses coupled with long-term motivational change and avoidance learning cannot be explained by nociceptive reflex...

... nociceptors by examining nociceptive behaviours and neurophysiological responses to extreme temperatures and potentially nocigenic chemicals. Crayfish ( Procambarus clarkii ) respond quickly and strongly to high temperatures, and neurons in the antenna show increased responses to transient high temperature...