.... In addition, myelopoiesis was strongly misregulated in fli1b mutants. Although the formation of the earliest myeloid progenitors – neutrophils and macrophages – was greatly reduced in fli1b mutants, this was compensated by the increased emergence of myeloid cells from the alternative hematopoietic site...

... of the cytokine. We observe a dose-dependent inflammatory response involving neutrophil expansion accompanied by tissue damage and reduced survival. Washout of tebufenozide permits inflammation resolution. We also establish the utility of this model for the identification of small molecule anti-inflammatory...