... transition to commitment to neurogenesis. This, in turn, leads to large-scale effects on chromatin organization and transcriptional landscape at later stages of neural development and presumably to diverging trajectories of neurons and other neural cells. Follow-up studies of direct targets, different...

..., and lobe measurements were averaged to provide the average lobe length, width, and depth per embryo or larvae. Zebrafish Valproic Acid Optic Tectum Neurogenesis Axonogenesis Dendritogenesis Brigham Young University http://dx.doi.org/10.13039/100006756 The superior colliculus...

... had cell-cycle arrest effects, we sought to determine whether branaplam may affect postnatal cerebellar development and brain neurogenesis. Here, we describe a novel approach for developmental neurotoxicity testing (DNT) of a central nervous system (CNS) active drug. The effects of orally administered...

... that mimic as much as possible the in vivo tumor ( Aldape et al., 2019 ). Neural stem cells Glioblastoma Organoid Neurogenesis 3D culture Brain tumor Summary: We describe a method to co-culture glioblastoma stem cells with human cerebral organoids in order to model tumor complexity...

..., and abnormal neurogenesis within the ventricular/subventricular zone lining the lateral ventricles. However, whether these mice have deficits in hippocampal neurogenesis was not addressed. Here, we demonstrate that adult Slc13a4 +/− mice have increased neurogenesis within the subgranular zone (SGZ...

... layers of cerebral cortex . Cereb. Cortex   19 , 2439 - 2450 . 10.1093/cercor/bhn260 Lim , D. A. and Alvarez-Buylla , A. ( 2016 ). The adult ventricular-subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis . Cold Spring Harbor Perspect. Biol.   8 , a018820 . 10.1101...

... neurogenesis and increase BrdU-uptake, indicative of enhanced proliferation, but while Plagl2 effects on proliferation are more immediate, Plag1 effects are delayed. Taken together, we found that the Plag proto-oncogenes genes are essential regulators of neocortical development and although Plag1 and Plagl2...

... , A. and Bally-Cuif , L. ( 2016 ). A comparative view of regenerative neurogenesis in vertebrates . Development   143 , 741 - 753 . 10.1242/dev.122796 Amamoto , R. , Huerta , V. G. L. , Takahashi , E. , Dai , G. , Grant , A. K. , Fu , Z. and Arlotta , P...

.... Notch Actomyosin Polarity Adhesion Neurogenesis Epithelia are highly polarised tissues that can be specialised for protection, absorption, secretion, transport or sensory perceptions. Hence, mechanisms controlling polarity and integrity of epithelial tissues are important for shaping tissues...

... correlation between morpholino-induced and mutant phenotypes in zebrafish . Dev. Cell   32 : 97 - 108 . 10.1016/j.devcel.2014.11.018 Krauss , S. , Johansen , T. , Korzh , V. and Fjose , A. ( 1991 ). Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis...

...Niurka Trujillo-Paredes; Concepción Valencia; Gilda Guerrero-Flores; Dulce-María Arzate; José-Manuel Baizabal; Magdalena Guerra-Crespo; Ayari Fuentes-Hernández; Iván Zea-Armenta; Luis Covarrubias ABSTRACT Notch signalling is a well-established pathway that regulates neurogenesis. However, little...

... that cytoophidium formation occurs during nutrient deprivation in cultured cells, as well as in quiescent and starved neuroblasts of the Drosophila larval central nervous system. We also show that cytoophidia formation is reversible during neurogenesis, indicating that filament formation regulates pyrimidine...

...Camille Belzil; Naoyuki Asada; Kei-ichiro Ishiguro; Takeo Nakaya; Kari Parsons; Valentina Pendolino; Gernot Neumayer; Marina Mapelli; Yoshihiro Nakatani; Kamon Sanada; Minh Dang Nguyen ABSTRACT Apical neural progenitors (aNPs) drive neurogenesis by means of a program consisting of self...

..., and they are implicated in human neurological disorders. However, the precise mechanisms that underlie generation of GABAergic neuron diversity in the midbrain–hindbrain region are poorly understood. Here, we show unique and overlapping requirements for the related bHLH proteins Tal1 and Tal2 in GABAergic neurogenesis...

... necessary and sufficient to determine the rate of neocortical neurogenesis. The molecular links underlying its seemingly distinct proliferative and post-proliferative functions remain unknown. Here we reveal an enriched expression of functional reelin receptors, largely of Apolipoprotein E Receptor 2...

.... ( 2002 ). Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 419 , 929 – 934 . 10.1038/nature01124 Soriano P. ( 1999 ). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21 , 70 – 71 . 10.1038/5007 Tronche...