... acetylated MTs and resistance to colchicine, while expression of E18 did not, indicating that E18 did not contribute to MT stabilization. Expression of all tau constructs reduced overall levels of neurofilaments (NFs) within axonal neurites, and distribution of NFs along neurite lengths. Since NFs...

...Edward F. Boumil; Rishel Vohnoutka; Sangmook Lee; Harish Pant; Thomas B. Shea ABSTRACT Neurofilaments (NFs) are thought to provide stability to the axon. We examined NF dynamics within axonal neurites of NB2a/d1 neuroblastoma by transient transfection with green fluorescent protein-tagged NF-heavy...

...Rishel Brenna Vohnoutka; Edward F. Boumil; Yuguan Liu; Atsuko Uchida; Harish C. Pant; Thomas B. Shea ABSTRACT Phosphorylation of the C-terminal tail of the heavy neurofilament subunit (NF-H) impacts neurofilament (NF) axonal transport and residence within axons by fostering NF-NF associations...

...Sangmook Lee; Thomas B. Shea ABSTRACT Neurofilaments (NFs) are thought to provide structural support to mature axons via crosslinking of cytoskeletal elements mediated by the C-terminal region of the high molecular weight NF subunit (NF-H). Herein, we inhibited NF-H expression in differentiating...