... with highly penetrant cranial and ocular defects that resemble human ALX1 -linked FND. alx1 and alx3 are expressed in anterior cranial neural crest (aCNC), which gives rise to the anterior neurocranium (ANC), anterior segment structures of the eye and vascular pericytes. Consistent with a functional...

...Jennifer C. Kasemeier-Kulesa; Morgan H. Romine; Jason A. Morrison; Caleb M. Bailey; Danny R. Welch; Paul M. Kulesa ABSTRACT Melanoma pathogenesis from normal neural crest-derived melanocytes is often fatal due to aggressive cell invasion throughout the body. The identification of signals...

...Sophie R. Miller; Surangi N. Perera; Clare V. H. Baker ABSTRACT Perivascular/mural cells originate from either the mesoderm or the cranial neural crest. Regardless of their origin, Notch signalling is necessary for their formation. Furthermore, in both chicken and mouse, constitutive Notch1...

...Tsutomu Motohashi; Natsuki Watanabe; Masahiro Nishioka; Yuhki Nakatake; Piao Yulan; Hiromi Mochizuki; Yoshifumi Kawamura; Minoru S. H. Ko; Naoki Goshima; Takahiro Kunisada ABSTRACT Neural crest cells (NC cells) are multipotent cells that emerge from the edge of the neural folds and migrate...

... nature of the crosstalk between mesoderm and neural crest progenitors and the involvement of endothelial cells within the cardio–craniofacial field are largely unclear. Here we show in the mouse that genetic ablation of vascular endothelial growth factor receptor 2 (Flk1) in the mesoderm results in early...

... for physiological and developmental processes such as wound healing, macrophage dispersion and neural crest cell migration; whereas its loss facilitates cancer cell invasion and metastatic dissemination. Different assays have been developed to analyze CIL in tissue culture models. However, these methods have...