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Keywords: NOTCH1
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Journal Articles
Biol Open (2016) 5 (5): 645–653.
Published: 22 April 2016
... at supraphysiological levels results in fully penetrant and rapid-onset T-cell acute lymphoblastic leukemia (T-ALL) in the mouse. Here, we show that PRDM14-induced T-ALLs are driven by NOTCH1, a frequently mutated driver of human T-ALL. Notch1 is activated in this murine model via RAG-dependent promoter deletions...
Includes: Supplementary data