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Keywords: NAD+
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Journal Articles
Biol Open (2019) 8 (10): bio044719.
Published: 17 October 2019
... diet (HFD). The level of NAD + and Sir2 expression upregulate the transcriptional activity of PGC-1α. Exercise improves cardiac NAD + level and PGC-1α activity. However, the relationship between exercise, NAD + /dSIR2/ PGC-1α pathway and lipotoxic cardiomyopathy remains unknown. In this study, flies...
Journal Articles
Biol Open (2017) 6 (2): 141–147.
Published: 23 December 2016
... dinucleotide (NAD + ) is essential for both generating energy in mitochondria and nuclear DNA repair through NAD + -consuming poly(ADP-ribose) polymerases (PARPs). We found alterations in NAD + salvage metabolism in Drosophila pink1 mutants and showed that a diet supplemented with the NAD + precursor...