... cardiac injury models in zebrafish often lack the important element of myocardial hypoxia. We introduce a larval zebrafish model in which cardiac damage is induced in by exposure to severe ambient hypoxia. Zebrafish Myocardial infarction Hypoxia Regeneration Cardiac output Recovery Animal...

... functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction...

..., myocardial infarction (MI) measured 26±3.5% of left ventricle in untreated rats. MI in rats treated with 3000 U/kg of rhEPO immediately after coronary ligation was 56% smaller. Pretreatment with L-NAME did not attenuate the beneficial effect of rhEPO on MI size, while MI size in rats treated with L-NAME...