... approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models that show high-risk features including multifocal tumors, vascular invasion, metastasis, and circulating tumor cells (CTCs). HepT1 cells were injected into the livers...

... subtle off target effects of these systems. Adeno-associated virus Liver disease Mouse model Genetic models Cancer Research UK http://dx.doi.org/10.13039/501100000289 A17196 The Wellcome Trust WT107492Z Animal models have improved our understanding and therapies...

... in this mouse model, the site where the exogenous gene is inserted is the 5′-UTR region. Normally, it seems that the inserted gene will knockout the gene at that site. However, the location where the foreign gene has been inserted is important: it seems that there is a possibility that abnormalities involving...

... features of cancers are essential for studying cancer and searching for promising diagnosis and treatment modalities. There are several models described for Rb, but none of them fully meet our requirements. The aim of this study was to create a novel xenograft-nude mouse-model with broad application...

.... , Morreau , H. , Bijman , J. and Scholte , B. J. ( 1995 ). A mouse model for the cystic fibrosis delta F508 mutation . EMBO J. 14 , 4403 - 4411 . Wang , Y. , Li , Y. , Liu , X. and Cho , W. C. S. ( 2013 ). Genetic and epigenetic studies for determining molecular...