... ). Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo . Development 125 , 5009 - 5018 . 10.1242/dev.125.24.5009 Bernard , O. ( 2007 ). Lim kinases, regulators of actin dynamics . Int. J. Biochem. Cell Biol . 39 , 1071 - 1076...

... and medullary areas. This study presents a CNN model capable of segmenting multiple classes of interest, including acute IRI-specific pathological changes, in a whole mouse kidney section and can provide insights into the distribution of pathological classes within the whole mouse kidney section. References...

...Tomohiro Tamari; Yoshihisa Ikeda; Kento Morimoto; Keiko Kobayashi; Saori Mizuno-Iijima; Shinya Ayabe; Akihiro Kuno; Seiya Mizuno; Atsushi Yoshiki ABSTRACT Genetically engineered mouse models are essential tools for understanding mammalian gene functions and disease pathogenesis. Genome editing...

... nociceptive hypersensitivity. In this study, we used fly and mouse nociceptive sensitization models to address these questions. In flies, InR mutants and larvae with sensory neuron-specific expression of RNAi transgenes targeting InR exhibited persistent mechanical hypersensitivity. Mice with a specific...

...S. M. Rolfe; S. M. Whikehart; A. M. Maga ABSTRACT The International Mouse Phenotyping Consortium (IMPC) has generated a large repository of three-dimensional (3D) imaging data from mouse embryos, providing a rich resource for investigating phenotype/genotype interactions. While the data is freely...

...Hiroki Inoue; Takayuki Sakurai; Kazuteru Hasegawa; Atsushi Suzuki; Yumiko Saga ABSTRACT In the mouse testis, sperm originate from spermatogonial stem cells (SSCs). SSCs give rise to spermatogonial progenitors, which expand their population until entering the differentiation process...

... branaplam were evaluated in the SMA neonatal mouse model ( SMN Δ 7 ), and in juvenile Wistar Hannover rats and Beagle dogs. Histopathological examination and complementary immunohistochemical studies focused on areas of neurogenesis in the cerebellum (mice, rats, and dogs), and the subventricular zone...

... cell implantation) ( n =2 for each day 5, 9, 14, 19, and 23 post-implantation, total n =10 for Renca/luc and Renca(HM)/luc, respectively). Fig. 2. Schematic representation of the in vivo selection process. Cell lines were intrarenally injected (orthotopic implantation) in mouse...

...Amy K. Wehn; Deborah R. Farkas; Carly E. Sedlock; Dibya Subedi; Deborah L. Chapman ABSTRACT The mouse T-box transcription factors T and Tbx6 are co-expressed in the primitive streak and have unique domains of expression; T is expressed in the notochord, while Tbx6 is expressed in the presomitic...

...John D. West; Pin-Chi Tang; Clare A. Everett; Gillian E. MacKay; Jean H. Flockhart; Margaret A. Keighren ABSTRACT The composition of adult mouse aggregation chimaeras is much more variable than X-inactivation mosaics. An early theoretical model proposed that almost all the extra variation...

...Claire S. Simon; Lu Zhang; Tao Wu; Weibin Cai; Nestor Saiz; Sonja Nowotschin; Chen-Leng Cai; Anna-Katerina Hadjantonakis ABSTRACT The GATA zinc-finger transcription factor GATA4 is expressed in a variety of tissues during mouse embryonic development and in adult organs. These include the primitive...

... hormone (FSH) stimulation was examined using an in vitro model of mouse cumulus-oocyte complexes (COCs). The results confirmed that Cx43 phosphorylation occurred twice during FSH treatment. Importantly, the second Cx43 phosphorylation was closely related to cAMP level reduction within oocytes, which...

... developing mouse neural tissue, in which HS had either been enzymatically removed by heparanase treatment or lacking either the HS modifying enzymes Hs2st ( Hs2st −/− tissue) or Hs6st1 ( Hs6st1 −/− tissue), with exogenous Fgf8 to gain insight on how HS and the function of these two HS modifying enzymes...

... to trace the fate of Tbx6 -expressing cells in wild-type and mutant embryos to explain some of the puzzling features of the mutant phenotype. We created an inducible Tbx6-creERT2 transgenic mouse in which cre expression closely recapitulates endogenous Tbx6 expression both temporally and spatially. Using...

... expression was relevant to the VC-mediated reduction of histone H3 lysine 9 methylation in SCNT embryos. Our study thus shows a simply applicable method to greatly improve mouse cloning efficiency, and furthers our understanding of how somatic nuclei acquire totipotency. * Authors for correspondence...

...Ryuhei Ogawa; Kyohei Fujita; Kazuo Ito ABSTRACT In the present study, we showed that the dorsal root ganglion (DRG) in the mouse embryo contains pluripotent stem cells (PSCs) that have developmental capacities equivalent to those of embryonic stem (ES) cells and induced pluripotent stem cells...

... pathologies such as Parkinson's disease, depression or autism. Here we investigated the role of En1 in early mid-hindbrain development, using multiple En1-ablated mouse models as well as lineage-tracing techniques, and observed the appearance of ectopic dopaminergic neurons, indistinguishable from midbrain...

... through dynamic imaging, and the precise action of germ cells that leads to the emergence of testicular morphology remains uncharacterized. Here, we report an agent-based model that simulates the mouse spermatogenic cycle on a cross-section of the seminiferous tubule over a time scale of hours to years...

... inflammatory cytokine TNF. We have mapped a spontaneously occurring mouse mutation with a loss of hair phenotype, curly bare ( cub ), to the Rhbdf2 locus, which encodes the iRhom2 protein. The cub deletion removes the first 268 amino acids of the iRhom2 protein but is not a loss of function. We have also...

.... , Rabbitts T. H. ( 2000 ). The T cell oncogene Tal2 is necessary for normal development of the mouse brain. Dev. Biol. 227 , 533 – 544 . 10.1006/dbio.2000.9920 Cantor A. B. , Orkin S. H. ( 2002 ). Transcriptional regulation of erythropoiesis: an affair involving multiple...