... deformation of the epidermis by mechanical forces exerted during morphogenesis. At present, the factors that contribute to aECM function are mostly unknown, including the aECM components themselves, their posttranslational regulators, and the pathways required for their secretion. Here we showed that two...

... morphogenesis. Following transient physical or pharmacological manipulations of embryo size, pre-gastrulation mouse embryos show remarkable plasticity to recover and resume normal development. However, it remains unclear how mechanisms driving lineage specification and morphogenesis respond to defects in cell...

... medium provided that the original work is properly attributed. Summary: This paper provides quantitative data on the growth of 58 structures of the human embryonic heart between weeks 4 and 8 of development. Human heart development Embryology Growth Morphogenesis The study...

... as a model system, we identify F-actin and microtubules as important determinants of how cells and tissues respond to Shroom induced contractility. Shroom Cytoskeleton Drosophila Morphogenesis Epithelia Tissue architecture is typically defined during specific stages of embryonic...

..., but their contribution to later events of morphogenesis are less understood. We have shown that epidermal enclosure requires the GTPase CED-10/Rac1 and WAVE/Scar complex, its effector, to promote protrusions that drive enclosure through the branch actin regulator Arp2/3. Our analysis here of RGA-8, a homolog of SH3BP1...

... cardiomyopathy. By combining combinations of mutant alleles, we show that cardiac specification depends primarily on an overall dosage of gata4/5/6 alleles rather than a specific gene. We also identify a specific role for gata6 in controlling ventricle morphogenesis through regulation of both the first...

...Sudipa June Chatterjee; Ruba Halaoui; Rebecca Catherine Deagle; Carlis Rejon; Luke McCaffrey ABSTRACT The mammary gland undergoes extensive expansion of a ductal network through the stroma during puberty and is an excellent model for understanding epithelial tube morphogenesis. To investigate...

... constriction and acts together with more widespread Fak activation. This study delineates signaling pathways that regulate basal constriction during brain morphogenesis. * Present address: Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53201. ‡ Present address...

... cytoskeletal control. In this work, we used laser scanning microscopy and electron microscopy to describe the major stages of cell wall formation in the centric diatom algae Aulacoseira islandica and to study the effect of various microtubule inhibitors on the morphogenesis of frustule elements. Our results...

... Lifeact-GFP Hydra polyps provide a powerful system for live imaging of actin dynamics during morphogenesis and development of a simple and ancestral animal model. Lifeact Epithelial cell Morphogenesis Cnidarian Tissue evagination Evolution Bending and folding of epithelial tissues...

... novel mechanisms of morphogenesis that appeared early in vertebrate evolution. Axolotl Evolution Morphogenesis Pronephros Senescence Zebrafish Cellular senescence has been, until recently, linked to aging and as a means to prevent aberrant cellular proliferation. Cells that become...

... tracking in vivo , this paper demonstrates that directional movements downstream of Gbx2 and Otx2 are important for otic and lens placode formation. Cell migration Lens Live imaging Morphogenesis Otic Peripheral nervous system Vertebrate cranial placodes give rise to crucial parts...

... ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Planar cell polarity Vangl2 Prickle Myosin II Xenopus Neural tube closure Morphogenesis Vertebrate...

...Chunqiao Liu; Chen Lin; Chun Gao; Helen May-Simera; Anand Swaroop; Tiansen Li ABSTRACT Planar cell polarity (PCP) signaling plays a critical role in tissue morphogenesis. In mammals, disruption of three of the six “core PCP” components results in polarity-dependent defects with rotated cochlear...

... unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Differential adhesive affinity hypothesis Cell adhesion Cell segregation Cell sorting Epithelial polarity Embryos Germinal layers Primitive endoderm Morphogenesis Self-assembly...

...Ignacio Flor-Parra; Manuel Bernal; Jacob Zhurinsky; Rafael R. Daga Summary Yeast cells are non-motile and are encased in a cell wall that supports high internal turgor pressure. The cell wall is also essential for cellular morphogenesis and cell division. Here, we report unexpected morphogenetic...

...Unisha Patel; Monn Monn Myat Summary The Drosophila embryonic salivary gland is formed by the invagination and collective migration of cells. Here, we report on a novel developmental role for receptor-type guanylyl cyclase at 76C, Gyc76C, in morphogenesis of the salivary gland. We demonstrate...

...Olivier Urwyler; Fabiola Cortinas-Elizondo; Beat Suter Summary Morphogenesis in multicellular organisms requires the careful coordination of cytoskeletal elements, dynamic regulation of cell adhesion and extensive cell migration. sosie ( sie ) is a novel gene required in various morphogenesis...